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L-779450

CAT: 0013-GTR19173299-05Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19173299-05Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L-779450 is a potent and selective ATP-competitive inhibitor of Raf kinase with an IC50 of 10 nM. It exhibits strong selectivity, showing over 70-fold, 30-fold, and 7-fold preference for Raf over Lck, GSK3β, and p38α, respectively. This inhibitor is a valuable tool for investigating Raf-mediated signaling pathways in cancer research, both in cellular and biochemical assays.
CAS Number
303727-31-3
Product Name Alternative
Autophagy, L779450, L-779450, Inhibitor, L 779450, inhibit, Raf, Raf kinases
Field of Research
Cell Biology, Signal Transduction
Purity
≥95% (May vary between batches)
Solubility
DMSO:60 mg/mL (172.51 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.75 mM)
Smiles
Oc1cc (ccc1Cl) -c1[nH]c (nc1-c1ccncc1) -c1ccccc1
Molecular Formula
C20H14ClN3O
Molecular Weight
347.8
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

L-779,450

2-chloro-5-(2-phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)phenol is a member of imidazoles.

CAS Number303727-31-3
PubChem CID9950176
IUPAC Name2-chloro-5-(2-phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)phenol
Molecular FormulaC20H14ClN3O
Molecular Weight347.8
XLogP4.2
Topological Polar Surface Area61.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count25
Formal Charge0
Complexity425
SMILES
C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC(=C(C=C4)Cl)O
InChI
InChI=1S/C20H14ClN3O/c21-16-7-6-15(12-17(16)25)19-18(13-8-10-22-11-9-13)23-20(24-19)14-4-2-1-3-5-14/h1-12,25H,(H,23,24)
InChIKey
WXJLXRNWMLWVFB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of L-779,450
CAS: 303727-31-3
CID: 9950176
Formula: C20H14ClN3O
MW: 347.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight347.8
XLogP34.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass347.0825398
Monoisotopic Mass347.0825398
Topological Polar Surface Area61.8 Ų
Heavy Atom Count25
Formal Charge0
Complexity425
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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