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Capivasertib

CAT: 0013-GTR19173092-08Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19173092-08Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Capivasertib (AZD5363) is an orally active, pan-AKT inhibitor targeting Akt1, Akt2, and Akt3 with low nanomolar potency. It demonstrates antitumor efficacy in preclinical models of breast cancer and is widely used in research exploring AKT signaling in oncology, supported by both in vitro and in vivo studies.
CAS Number
1143532-39-1
Product Name Alternative
Inhibitor, inhibit, mTOR (p70S6K), Akt, AZD 5363, Autophagy, AZD5363, AZD-5363, Akt1, Akt2, Akt3, Capivasertib, Protein kinase B, PKB, PKA
Field of Research
Cell Biology, Signal Transduction
Purity
97.59% (May vary between batches)
Solubility
DMSO:130 mg/mL (303.09 mM) ; Ethanol:1 mg/mL (2.33 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:8 mg/mL (18.65 mM) ; H2O:Insoluble
Smiles
NC1 (CCN (CC1) c1ncnc2[nH]ccc12) C (=O) N[C@@H] (CCO) c1ccc (Cl) cc1
Molecular Formula
C21H25ClN6O2
Molecular Weight
428.92
References & Citations
Petros A Tyrakis 1, Domen Kampjut 1, Georgina F Steele 1, H Jonathan G Lindström 1, Deborah Chirnomas 1, Benjamin D Hopkins 2, Marcus D Goncalves 3, Siddhartha Mukherjee 4, Lewis C Cantley 5, Oliver D K Maddocks 6 Multi-node inhibition targeting mTORC1, mTORC2 and PI3Kα potently inhibits the PI3K/AKT/mTOR pathway in endometrial and breast cancer models Br J Cancer ., (2025)
Pubmed id
40360883
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Capivasertib

Capivasertib is an aminopiperidine that is piperidine substituted by 7H-pyrrolo[2,3-d]pyrimidin-4-yl, amino, and [(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]aminocarbonyl groups at positions 1, 4, and 4, respectively. It is a pan-AKT kinase inhibitor used in combination with fulvestrant for the treatment of adult patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, locally advanced or metastatic breast cancer with one or more PIK3CA/AKT1/PTEN-alterations. It has a role as an antineoplastic agent and an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It is a secondary carboxamide, a primary alcohol, a pyrrolopyrimidine, an aminopiperidine, a piperidinecarboxamide and a member of monochlorobenzenes.

CAS Number1143532-39-1
PubChem CID25227436
IUPAC Name4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
Molecular FormulaC21H25ClN6O2
Molecular Weight428.9
XLogP1.7
Topological Polar Surface Area120
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count30
Formal Charge0
Complexity580
SMILES
C1CN(CCC1(C(=O)N[C@@H](CCO)C2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4
InChI
InChI=1S/C21H25ClN6O2/c22-15-3-1-14(2-4-15)17(6-12-29)27-20(30)21(23)7-10-28(11-8-21)19-16-5-9-24-18(16)25-13-26-19/h1-5,9,13,17,29H,6-8,10-12,23H2,(H,27,30)(H,24,25,26)/t17-/m0/s1
InChIKey
JDUBGYFRJFOXQC-KRWDZBQOSA-N
Chemical Structure
2D Structure
2D structure of Capivasertib
CAS: 1143532-39-1
CID: 25227436
Formula: C21H25ClN6O2
MW: 428.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight428.9
XLogP31.7
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass428.1727518
Monoisotopic Mass428.1727518
Topological Polar Surface Area120 Ų
Heavy Atom Count30
Formal Charge0
Complexity580
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BUP12094-01Capivasertib
S8019-5mgCapivasertib (AZD5363)
CS-O-59072Capivasertib-d4
HY-15431R-01Capivasertib (Standard)
TYD-02708-01(R) -Capivasertib
AR-C05983-01Capivasertib-d6
CS-O-64825Capivasertib-d5
CS-O-60041N-Nitroso Capivasertib
RM-C017603-01Capivasertib Impurity 3
RM-C017604-01Capivasertib Impurity 4

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