Products for Research Use Only
RegisterLogin

Sephin1

CAT: 0013-GTR19172986-02Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19172986-02Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Sephin1 (IFB-088) is a selective small molecule inhibitor of GADD34 (PPP1R15A) . By blocking this stress-induced regulatory subunit, it prolongs eIF2α phosphorylation, thereby modulating the integrated stress response. This action has shown protective effects in preclinical models of protein misfolding diseases, such as neurodegenerative disorders.
CAS Number
13098-73-2
Product Name Alternative
(E/Z) -Icerguastat, (E/Z) -Sephin1, IFB 088, IFB088, IFB-088, NSC65390, NSC-65390, NSC 65390, inhibit, Inhibitor, Phosphatase, phosphatase PPP1R15A, PPP1R15A, PPP1R15B, Sephin-1, Sephin1, protein misfolding diseases
Field of Research
Metabolism Research
Purity
99.24% (May vary between batches)
Solubility
DMSO:7 mg/mL (35.6 mM) ; H2O:insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (5.09 mM)
Smiles
C (=NNC (=N) N) C1=C (Cl) C=CC=C1
Molecular Formula
C8H9ClN4
Molecular Weight
196.64
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Icerguastat

Icerguastat is an organic molecular entity. It has a role as an inhibitor.

CAS Number13098-73-2
PubChem CID9561611
IUPAC Name2-[(E)-(2-chlorophenyl)methylideneamino]guanidine
Molecular FormulaC8H9ClN4
Molecular Weight196.64
XLogP1.1
Topological Polar Surface Area76.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Heavy Atom Count13
Formal Charge0
Complexity210
SMILES
C1=CC=C(C(=C1)/C=N/N=C(N)N)Cl
InChI
InChI=1S/C8H9ClN4/c9-7-4-2-1-3-6(7)5-12-13-8(10)11/h1-5H,(H4,10,11,13)/b12-5+
InChIKey
PDWJALXSRRSUHR-LFYBBSHMSA-N
Chemical Structure
2D Structure
2D structure of Icerguastat
CAS: 13098-73-2
CID: 9561611
Formula: C8H9ClN4
MW: 196.64
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight196.64
XLogP31.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass196.0515740
Monoisotopic Mass196.0515740
Topological Polar Surface Area76.8 Ų
Heavy Atom Count13
Formal Charge0
Complexity210
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19032390-01Recombinant Human Septin-12 (SEPTIN12)
GTR19033942Recombinant Human Septin-5/SEPTIN5
GTR18097580Septin 8/Septin8 Rabbit Polyclonal Antibody
GTR18097624Septin 2/SEPTIN2 Rabbit Polyclonal Antibody
GTR18097613Septin 3/SEPTIN3 Rabbit Polyclonal Antibody
GTR18875230-01Rat Septin 9 (SEPTIN9) ELISA Kit
GTR18183372Septin 11/SEPTIN11 Rabbit Polyclonal Antibody
GTR18542721Septin 2/SEPTIN2 Rabbit Polyclonal Antibody (FITC)
GTR18542719Septin 2/SEPTIN2 Rabbit Polyclonal Antibody (APC)
GTR18542717Septin 3/SEPTIN3 Rabbit Polyclonal Antibody (Biotin)

Alternative Products

CatalogName
MBS3613145-01Sephin1
A12791-50Sephin1 (Icerguastat) 50mg
T69440-01Sephin1 Hydrochloride
A12791-200Sephin1 (Icerguastat) 200mg
A12791-100Sephin1 (Icerguastat) 100mg
A12791-25Sephin1 (Icerguastat) 25mg
A12791-10Sephin1 (Icerguastat) 10mg
A12791-5Sephin1 (Icerguastat) 5mg
A12791-10mM-DSephin1 (Icerguastat) 10mM * 1mL in DMSO
bs-60280C-01Sephin1, PPP1R15A Protein Phosphatase Inhibitor

Popular Products