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NVP-BEZ235

CAT: 0013-GTR19172779-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19172779-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dactolisib (BEZ235) is a potent, orally active dual inhibitor of PI3K and mTOR kinase, with low nanomolar IC50 values against all PI3K isoforms and mTOR. It is widely used in preclinical research to investigate the PI3K/AKT/mTOR signaling pathway in cancer models, both in vitro and in vivo.
CAS Number
915019-65-7
Product Name Alternative
Dactolisib, BEZ 235, BEZ235, BEZ-235, Autophagy, ATM, ATR, Inhibitor, Mammalian target of Rapamycin, NVP-BEZ235, NVP-BEZ-235, NVP-BEZ 235, p110α, p110γ, p110δ, inhibit, mTOR (p70S6K), mTOR, PI3K, Phosphoinositide 3-kinase
Field of Research
Cardiovascular Research, Cell Biology
Purity
>98%
Bioactivity
PI 3-K and mTOR inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 1 mg/ml with warming) or in DMF (up to 10 mg/ml, dissolves slowly, requires heating to 75°C) .
Smiles
O=C1N (C=2C=3C (N=CC2N1C) =CC=C (C3) C4=CC5=C (N=C4) C=CC=C5) C6=CC=C (C (C#N) (C) C) C=C6
Molecular Formula
C30H23N5O
Molecular Weight
469.55
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
2-Methyl-2-{4-[3-methyl-2-oxo-8- (quinolin-3-yl) -2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl]phenyl}propanenitrile

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Alternative Products

CatalogName
A8246-50BEZ235 (NVP-BEZ235)
BC1006-500BEZ235 (NVP-BEZ235), > 99%
MBS576124BEZ235 (NVP-BEZ235, Dactolisib)
abx076687-01NVP-BEZ235
A10133-500BEZ235 (NVP-BEZ235, Dactolisib) 500mg
SC0330-5mgNVP-BEZ235 (PI3K inhibitor)
TBI2153-50MGNVP-BEZ235, PI 3-K and mTOR inhibitor
410-03BEZ235
A10133-100BEZ235 100mg
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