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Tropisetron

CAT: 0013-GTR19172705-04Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19172705-04Size:50 mg
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Description
Tropisetron (ICS 205-930) is a dual-acting small molecule, functioning as a potent α7-nicotinic acetylcholine receptor agonist and a 5-HT3 receptor antagonist with respective Ki values of 6.9 nM and 5.3 nM. It is widely used in neuroscience research to investigate cholinergic and serotonergic systems in models of cognition, inflammation, and nausea, both in vitro and in vivo.
CAS Number
89565-68-4
Product Name Alternative
Serotonin Receptor, α7 nAChR, Tropisetronum, Tropisteron, Tropisetron, Inhibitor, ICS 205-930, inhibit, nAChR, Nicotinic acetylcholine receptors, 5HTReceptor, 5-hydroxytryptamine Receptor, 5HT Receptor, 5-HT Receptor, 5-HT3
Field of Research
Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Molecular Biology, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.68% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.03 mM) ; DMSO:65 mg/mL (228.59 mM) ; H2O:50 mg/mL (175.84 mM)
Smiles
CN1[C@H]2CC[C@H]1CC (C2) OC (=O) c1c[nH]c2ccccc12
Molecular Formula
C17H20N2O2
Molecular Weight
284.35
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Tropisetron

Tropisetron is an indolyl carboxylate ester obtained by formal condensation of the carboxy group of indole-3-carboxylic acid with the hydroxy group of tropine. It has a role as a trypanocidal drug, a nicotinic acetylcholine receptor agonist, a serotonergic antagonist, an immunomodulator, an antiemetic, a neuroprotective agent, an anti-inflammatory agent and an apoptosis inhibitor. It is an azabicycloalkane, an indolyl carboxylate ester and a tertiary amino compound. It is functionally related to a tropine and an indole-3-carboxylic acid. It is a conjugate base of a tropisetron(1+).

CAS Number89565-68-4
PubChem CID656665
IUPAC Name[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 1H-indole-3-carboxylate
Molecular FormulaC17H20N2O2
Molecular Weight284.35
XLogP3.8
Topological Polar Surface Area45.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count21
Formal Charge0
Complexity400
SMILES
CN1[C@@H]2CC[C@H]1CC(C2)OC(=O)C3=CNC4=CC=CC=C43
InChI
InChI=1S/C17H20N2O2/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16/h2-5,10-13,18H,6-9H2,1H3/t11-,12+,13?
InChIKey
ZNRGQMMCGHDTEI-FUNVUKJBSA-N
Chemical Structure
2D Structure
2D structure of Tropisetron
CAS: 89565-68-4
CID: 656665
Formula: C17H20N2O2
MW: 284.35
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight284.35
XLogP33.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass284.152477885
Monoisotopic Mass284.152477885
Topological Polar Surface Area45.3 Ų
Heavy Atom Count21
Formal Charge0
Complexity400
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA5012-25Tropisetron
FT28617-01Tropisetron hydrochloride
TRC-T892702-2.5MGTropisetron-d5
MBS576795Tropisetron HCl
sc-474141ATropisetron-d4
A11226-10Tropisetron 10mg
A11226-5Tropisetron 5mg

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