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Merestinib

CAT: 0013-GTR19172276-02Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19172276-02Size:2 mg
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Description
Merestinib (LY2801653) is a potent and selective c-Met inhibitor (Ki: 2 nM) that blocks phosphorylation and downstream signaling, inducing apoptosis in c-Met-dysregulated tumors. It has demonstrated antitumor activity in both in vitro cellular assays and in vivo xenograft models across various cancer research fields, including hepatocellular carcinoma and non-small cell lung cancer.
CAS Number
1206799-15-6
Product Name Alternative
Inhibit, LY2801653, LY-2801653, LY 2801653, Met, Inhibitor, HGFR, Merestinib, FLT3, DDR, Fms like tyrosine kinase 3, DiscoidinDomainReceptor, Discoidin Domain Receptor (DDR), Discoidin Domain Receptor, DiscoidinDomainReceptor (DDR), cMet, c-Met, cMet/HGFR, c-Met/HGFR, Cluster of differentiation antigen 135, CD135, ROS, ROS Kinase, ROSKinase
Field of Research
Cardiovascular Research, Immunology & Inflammation, Signal Transduction
Purity
95.00% (May vary between batches)
Solubility
DMSO:16 mg/mL (28.96 mM) ; Ethanol:93 mg/mL (168.32 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.97 mM)
Smiles
O (C1=C (C=C2C (=C1) C=NN2C) C=3C=NNC3) C4=C (F) C=C (NC (=O) C=5C (=O) N (C (C) =CC5) C6=CC=C (F) C=C6) C=C4
Molecular Formula
C30H22F2N6O3
Molecular Weight
552.53
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Merestinib

Merestinib has been used in trials studying the treatment of Cancer, Solid Tumor, Advanced cancer, ColoRectal Cancer, and Metastatic Cancer, among others.

CAS Number1206799-15-6
PubChem CID44603533
IUPAC NameN-[3-fluoro-4-[1-methyl-6-(1H-pyrazol-4-yl)indazol-5-yl]oxyphenyl]-1-(4-fluorophenyl)-6-methyl-2-oxopyridine-3-carboxamide
Molecular FormulaC30H22F2N6O3
Molecular Weight552.5
XLogP4.7
Topological Polar Surface Area105
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Heavy Atom Count41
Formal Charge0
Complexity1050
SMILES
CC1=CC=C(C(=O)N1C2=CC=C(C=C2)F)C(=O)NC3=CC(=C(C=C3)OC4=C(C=C5C(=C4)C=NN5C)C6=CNN=C6)F
InChI
InChI=1S/C30H22F2N6O3/c1-17-3-9-23(30(40)38(17)22-7-4-20(31)5-8-22)29(39)36-21-6-10-27(25(32)12-21)41-28-11-18-16-35-37(2)26(18)13-24(28)19-14-33-34-15-19/h3-16H,1-2H3,(H,33,34)(H,36,39)
InChIKey
QHADVLVFMKEIIP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Merestinib
CAS: 1206799-15-6
CID: 44603533
Formula: C30H22F2N6O3
MW: 552.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight552.5
XLogP34.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass552.17214491
Monoisotopic Mass552.17214491
Topological Polar Surface Area105 Ų
Heavy Atom Count41
Formal Charge0
Complexity1050
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T3455-01Merestinib
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E7462Merestinib dihydrochloride
S7014-5mgMerestinib (LY2801653)
A12557-1LY2801653 (Merestinib) 1mg
A12557-500LY2801653 (Merestinib) 500mg
A12557-2LY2801653 (Merestinib) 2mg

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