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EED-226

CAT: 0013-GTR19172274-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19172274-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EED226 is a potent and selective small molecule inhibitor of the Embryonic Ectoderm Development (EED) protein, demonstrating an IC50 of 22 nM. Its oral bioavailability facilitates research into PRC2 function in both cellular assays and animal models for oncology and developmental biology studies.
CAS Number
2083627-02-3
Product Name Alternative
Antitumor, inhibit, K27me3, EED, EED-226, EED 226, EED226, HistoneMethyltransferase, Histone Methyltransferase, Inhibitor, PRC2
Field of Research
Epigenetics & Chromatin, Immunology & Inflammation
Purity
>98%
Bioactivity
PRC2 methyltransferase inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml)
Smiles
N (CC1=CC=CO1) C=2N3C (C (=CN2) C4=CC=C (S (C) (=O) =O) C=C4) =NN=C3
Molecular Formula
C17H15N5O3S
Molecular Weight
369.40
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
N- (Furan-2-ylmethyl) -8- (4-methylsulfonylphenyl) -[1,2,4]triazolol[4,3-c) pyrimidine-5-amine

Chemical Information

Eed226

a polycomb repressive complex 2 inhibitor; structure in first source

CAS Number2083627-02-3
PubChem CID123132228
IUPAC NameN-(furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine
Molecular FormulaC17H15N5O3S
Molecular Weight369.4
XLogP2.3
Topological Polar Surface Area111
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count26
Formal Charge0
Complexity575
SMILES
CS(=O)(=O)C1=CC=C(C=C1)C2=CN=C(N3C2=NN=C3)NCC4=CC=CO4
InChI
InChI=1S/C17H15N5O3S/c1-26(23,24)14-6-4-12(5-7-14)15-10-19-17(22-11-20-21-16(15)22)18-9-13-3-2-8-25-13/h2-8,10-11H,9H2,1H3,(H,18,19)
InChIKey
DYIRSNMPIZZNBK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Eed226
CAS: 2083627-02-3
CID: 123132228
Formula: C17H15N5O3S
MW: 369.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight369.4
XLogP32.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass369.08956053
Monoisotopic Mass369.08956053
Topological Polar Surface Area111 Ų
Heavy Atom Count26
Formal Charge0
Complexity575
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
B1845-5EED-226
448077-01EED 226
BE165158-01EED 226 monohydrate
TBI4021-25MGEED-226, PRC2 methyltransferase inhibitor
302407Eed (Polycomb Protein EED, Eed)
MBS6455721-01Eed (Polycomb Protein EED, Eed) (PE)
MBS6455714-01Eed (Polycomb Protein EED, Eed) (FITC)
MBS6455712-01Eed (Polycomb Protein EED, Eed) (APC)
MBS6455715-01Eed (Polycomb Protein EED, Eed) (HRP)
MBS6455713-01Eed (Polycomb Protein EED, Eed) (Biotin)

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