Products for Research Use Only
RegisterLogin

GSK180736A

CAT: 0013-GTR19172215-09Size: 500 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19172215-09Size:500 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
GSK180736A is a potent and selective GRK2 inhibitor (IC50 = 0.77 μM) with over 100-fold selectivity for GRK2 over other GRK isoforms. It also effectively inhibits ROCK1 (IC50 = 100 nM) and shows weaker activity against PKA. This compound is a valuable research tool for investigating GPCR signaling and Rho-ROCK pathways in cardiovascular and fibrotic disease models.
CAS Number
817194-38-0
Product Name Alternative
ROK, ROCK, Rho-kinase, Rho-associated kinase, Rho-associated protein kinase, PKA, Inhibitor, inhibit, GSK180736, GSK-180736, GSK180736A, GSK-180736A, GSK 180736, GRK1, GRK2, GRK5
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.16% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.47 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:60 mg/mL (164.22 mM) ; Ethanol:3 mg/mL (8.21 mM)
Smiles
CC1=C (C (NC (=O) N1) c1ccc (F) cc1) C (=O) Nc1ccc2[nH]ncc2c1
Molecular Formula
C19H16FN5O2
Molecular Weight
365.36
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Gsk180736A

GRK2 Inhibitor

CAS Number817194-38-0
PubChem CID11233873
IUPAC Name4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide
Molecular FormulaC19H16FN5O2
Molecular Weight365.4
XLogP1.7
Topological Polar Surface Area98.9
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count27
Formal Charge0
Complexity632
SMILES
CC1=C(C(NC(=O)N1)C2=CC=C(C=C2)F)C(=O)NC3=CC4=C(C=C3)NN=C4
InChI
InChI=1S/C19H16FN5O2/c1-10-16(17(24-19(27)22-10)11-2-4-13(20)5-3-11)18(26)23-14-6-7-15-12(8-14)9-21-25-15/h2-9,17H,1H3,(H,21,25)(H,23,26)(H2,22,24,27)
InChIKey
HEAIGWIZTYAQTC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Gsk180736A
CAS: 817194-38-0
CID: 11233873
Formula: C19H16FN5O2
MW: 365.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight365.4
XLogP31.7
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass365.12880293
Monoisotopic Mass365.12880293
Topological Polar Surface Area98.9 Ų
Heavy Atom Count27
Formal Charge0
Complexity632
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA4483-5.1GSK180736A
S8489-10mgGSK180736A (GSK180736)
A20736-500GSK180736A 500mg
A20736-100GSK180736A 100mg
A20736-25GSK180736A 25mg
A20736-10GSK180736A 10mg
A20736-50GSK180736A 50mg
A20736-5GSK180736A 5mg
A20736-2GSK180736A 2mg
A20736-1GSK180736A 1mg

Popular Products