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RO8994

CAT: 0013-GTR19172209-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19172209-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RO8994 is a potent and selective spiroindolinone-based MDM2 inhibitor, exhibiting IC50 values of 20 nM in MTT proliferation assays and 5 nM in HTRF binding assays. This compound is a valuable research tool for studying p53-MDM2 interactions in cancer biology, applicable in both in vitro and in vivo experimental models.
CAS Number
1309684-94-3
Product Name Alternative
Inhibitor, Mdm2, MDM-2/p53, inhibit, P53, E3 ligating enzyme, E3Enzyme, E2 Enzyme, E2 conjugating enzyme, E2Enzyme, E3 Enzyme, E1/E2/E3 Enzyme, E1Enzyme, E1 activating enzyme, E1 Enzyme, RO 8994, RO8994, RO-8994, Ubiquitin activating enzyme, Ubiquitin conjugating enzyme, Ubiquitin ligase
Field of Research
Cell Biology, Protein Biochemistry
Purity
98.87% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.26 mM) ; DMSO:50 mg/mL (81.5 mM)
Smiles
COc1cc (ccc1NC (=O) [C@@H]1N[C@@H] (CC (C) (C) C) [C@]2 ([C@H]1c1cccc (Cl) c1F) C (=O) Nc1cc (Cl) ccc21) C (N) =O
Molecular Formula
C31H31Cl2FN4O4
Molecular Weight
613.51
Storage Conditions
-20°C
Notes
For research use only.

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BA2904-10RO8994
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A20865-1RO8994 1mg
A20865-2RO8994 2mg
A20865-100RO8994 100mg
A20865-50RO8994 50mg
A20865-5RO8994 5mg
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