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U-73122

CAT: 0013-GTR19172038-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19172038-01Size:5 mg
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Description
U-73122 is a potent phospholipase C (PLC) inhibitor that suppresses agonist-triggered intracellular calcium mobilization in platelets and polymorphonuclear leukocytes (PMNs) . It is widely used in vitro to study calcium signaling pathways in immunology, inflammation, and cardiovascular research.
CAS Number
112648-68-7
Product Name Alternative
Phospholipase, U 73122, U73122, U-73122, PLC, LOX, inhibit, Lipoxygenase, Inhibitor, Ferroptosis
Field of Research
Cell Biology
Purity
>98%
Bioactivity
Phospholipase C inhibitor
Form
Powder
Solubility
Very soluble in Methylene chloride or Chloroform. Slightly soluble in DMSO (up to 2 mg/ml) or in Ethanol (up to 1 mg/ml) .
Smiles
COc1ccc2[C@H]3CC[C@]4 (C) [C@H] (CC[C@H]4[C@@H]3CCc2c1) NCCCCCCN1C (=O) C=CC1=O
Molecular Formula
C29H40N2O3
Molecular Weight
464.7
Storage Conditions
RT
Notes
For research use only.
Other Product Names
1-[6-[[ (17β) -3-Methoxyestra-1,3,5 (10) -trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione

Chemical Information

1-(6-(((17beta)-3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione

U-73122 is an aza-steroid that is 3-O-methyl-17beta-estradiol in which the 17beta-hydroxy group is replaced by a 6-(maleimid-1-yl)hexylamino group. An inibitor of phospholipase C. It has a role as an EC 3.1.4.11 (phosphoinositide phospholipase C) inhibitor. It is an aromatic ether, an aza-steroid and a member of maleimides. It is functionally related to a 17beta-estradiol.

CAS Number112648-68-7
PubChem CID104794
IUPAC Name1-[6-[[(8R,9S,13S,14S,17S)-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]amino]hexyl]pyrrole-2,5-dione
Molecular FormulaC29H40N2O3
Molecular Weight464.6
XLogP4
Topological Polar Surface Area58.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count9
Heavy Atom Count34
Formal Charge0
Complexity763
SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2NCCCCCCN4C(=O)C=CC4=O)CCC5=C3C=CC(=C5)OC
InChI
InChI=1S/C29H40N2O3/c1-29-16-15-23-22-10-8-21(34-2)19-20(22)7-9-24(23)25(29)11-12-26(29)30-17-5-3-4-6-18-31-27(32)13-14-28(31)33/h8,10,13-14,19,23-26,30H,3-7,9,11-12,15-18H2,1-2H3/t23-,24-,25+,26+,29+/m1/s1
InChIKey
LUFAORPFSVMJIW-ZRJUGLEFSA-N
Chemical Structure
2D Structure
2D structure of 1-(6-(((17beta)-3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione
CAS: 112648-68-7
CID: 104794
Formula: C29H40N2O3
MW: 464.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight464.6
XLogP34
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count9
Exact Mass464.30389314
Monoisotopic Mass464.30389314
Topological Polar Surface Area58.6 Ų
Heavy Atom Count34
Formal Charge0
Complexity763
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
BML-ST391-0005U-73122
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A14339-100U 73122 100mg
A14339-50U 73122 50mg
A14339-10U 73122 10mg
A14339-5U 73122 5mg
A14339-25U 73122 25mg
A14339-2U 73122 2mg
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