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Talazoparib

CAT: 0013-GTR19172028-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19172028-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Talazoparib (LT-673) is a potent, orally bioavailable inhibitor of PARP1 and PARP2. It exerts its anti-tumor effects by inhibiting PARP enzymatic activity and trapping the PARP-DNA complex, leading to synthetic lethality in BRCA-deficient cells. This mechanism has demonstrated efficacy in both in vitro cytotoxicity assays and in vivo xenograft models of various cancers.
CAS Number
1207456-01-6
Product Name Alternative
BRCA1/2, breast cancer, anticancer, BMN 673, BMN673, BMN-673, PARP, PARP-mediated, PARylation, LT673, LT-673, LT 673, MX-1, inhibit, Inhibitor, poly ADP ribose polymerase, Talazoparib
Field of Research
Epigenetics & Chromatin, Molecular Biology
Purity
97.02% (May vary between batches)
Solubility
DMSO:36 mg/mL (94.65 mM) ;10% DMSO+90% Saline:0.1 mg/mL (0.26 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
Cn1ncnc1[C@@H]1[C@H] (Nc2cc (F) cc3c2c1n[nH]c3=O) c1ccc (F) cc1
Molecular Formula
C19H14F2N6O
Molecular Weight
380.35
Storage Conditions
-20°C
Notes
For research use only.

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