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GSK-690693

CAT: 0013-GTR19171993-06Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19171993-06Size:50 mg
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Description
GSK-690693 is a potent, pan-Akt inhibitor with IC50 values of 2, 13, and 9 nM for Akt1, Akt2, and Akt3, respectively. It also inhibits related AGC kinases like PKA and PKC. This compound has been used in preclinical research to study PI3K/Akt signaling in cancer models, both in vitro and in vivo.
CAS Number
937174-76-0
Product Name Alternative
Protein kinase B, PKB, PKCθ, PKCη, Serine Protease, SerineProtease, PrkX, inhibit, GSK 690693, GSK690693, GSK-690693, Inhibitor, AMP-activated protein kinase, AMPK, Autophagy, Akt, Akt1, Akt3
Field of Research
Cell Biology, Epigenetics & Chromatin, Protein Biochemistry, Signal Transduction
Purity
97.54% (May vary between batches)
Solubility
DMF:soluble; DMSO:18.33 mg/mL (43.08 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.7 mM)
Smiles
CCn1c (nc2c (ncc (OC[C@H]3CCCNC3) c12) C#CC (C) (C) O) -c1nonc1N
Molecular Formula
C21H27N7O3
Molecular Weight
425.48
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Gsk 690693

GSK690693 is a member of the class of imidazopyridines that is 4-(1-ethylimidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol carrying additional 2-(4-amino-1,2,5-oxadiazol-3-yl and [(3S)-piperidin-3-yl]methoxy substituents at positions 4 and 7 respectively. It has a role as an antineoplastic agent and an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It is a member of piperidines, a tertiary alcohol, an aromatic amine, an aromatic ether, a 1,2,5-oxadiazole, an imidazopyridine, a primary amino compound and an acetylenic compound.

CAS Number937174-76-0
PubChem CID16725726
IUPAC Name4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[[(3S)-piperidin-3-yl]methoxy]imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol
Molecular FormulaC21H27N7O3
Molecular Weight425.5
XLogP0.3
Topological Polar Surface Area137
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Heavy Atom Count31
Formal Charge0
Complexity680
SMILES
CCN1C2=C(C(=NC=C2OC[C@H]3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N
InChI
InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1
InChIKey
KGPGFQWBCSZGEL-ZDUSSCGKSA-N
Chemical Structure
2D Structure
2D structure of Gsk 690693
CAS: 937174-76-0
CID: 16725726
Formula: C21H27N7O3
MW: 425.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight425.5
XLogP30.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Exact Mass425.21753775
Monoisotopic Mass425.21753775
Topological Polar Surface Area137 Ų
Heavy Atom Count31
Formal Charge0
Complexity680
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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