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Tirbanibulin

CAT: 0013-GTR19171932-05Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19171932-05Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tirbanibulin (KX2-391) is a substrate-targeted, highly selective Src kinase inhibitor. It has shown anti-tumor efficacy in preclinical in vivo models of colon, pancreatic, prostate, and breast cancers, supporting its investigation as a targeted protein kinase inhibitor in oncology research.
CAS Number
897016-82-9
Product Name Alternative
Inhibitor, inhibit, KX 01, KX-01, KX01, KX2-391, Microtubule Associated, Microtubule/Tubulin, MicrotubuleAssociated, Src, Src (Hep 3B), Src (Hep G2), Src (HuH7), Src (PLC/PRF/5), Tirbanibulin
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Purity
99.43% (May vary between batches)
Solubility
DMSO:84.17 mg/mL (195.05 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.65 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
O=C (Cc1ccc (cn1) -c1ccc (OCCN2CCOCC2) cc1) NCc1ccccc1
Molecular Formula
C26H29N3O3
Molecular Weight
431.53
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Tirbanibulin

Tirbanibulin is a member of the class of pyridines that is pyridine substituted by 2-(benzylamino)-2-oxoethyl and 4-[2-(morpholin-4-yl)ethoxy]phenyl groups at positions 2 and 5, respectively. It is a dual inhibitor of Src kinase and tubulin and approved by the FDA for the topical treatment of actinic keratosis on the face or scalp. It has a role as an antineoplastic agent, a microtubule-destabilising agent, an apoptosis inducer and an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a secondary carboxamide, a member of pyridines, an aromatic ether and a member of morpholines.

CAS Number897016-82-9
PubChem CID23635314
IUPAC NameN-benzyl-2-[5-[4-(2-morpholin-4-ylethoxy)phenyl]-2-pyridinyl]acetamide
Molecular FormulaC26H29N3O3
Molecular Weight431.5
XLogP2.9
Topological Polar Surface Area63.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count9
Heavy Atom Count32
Formal Charge0
Complexity540
SMILES
C1COCCN1CCOC2=CC=C(C=C2)C3=CN=C(C=C3)CC(=O)NCC4=CC=CC=C4
InChI
InChI=1S/C26H29N3O3/c30-26(28-19-21-4-2-1-3-5-21)18-24-9-6-23(20-27-24)22-7-10-25(11-8-22)32-17-14-29-12-15-31-16-13-29/h1-11,20H,12-19H2,(H,28,30)
InChIKey
HUNGUWOZPQBXGX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Tirbanibulin
CAS: 897016-82-9
CID: 23635314
Formula: C26H29N3O3
MW: 431.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight431.5
XLogP32.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count9
Exact Mass431.22089180
Monoisotopic Mass431.22089180
Topological Polar Surface Area63.7 Ų
Heavy Atom Count32
Formal Charge0
Complexity540
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
S2700-200mgTirbanibulin
HY-10340A-01Tirbanibulin (dihydrochloride)
564393Tirbanibulin mesylate
HY-10340R-01Tirbanibulin (Standard)
T15674Tirbanibulin dihydrochloride
HY-10340B-01Tirbanibulin (Mesylate)

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