Products for Research Use Only
RegisterLogin

MSC2504877

CAT: 0013-GTR19171841-02Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19171841-02Size:1 ml x 10 mM (in DMSO)
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
MSC2504877 is a tankyrase inhibitor that synergizes with clinical CDK4/6 inhibitors like palbociclib. It blocks the compensatory upregulation of Cyclin D2 and Cyclin E2 and augments phospho-Rb suppression, enhancing G1 cell cycle arrest in cancer research models, both in vitro and in vivo.
CAS Number
1460286-21-8
Product Name Alternative
MSC 2504877, MSC2504877, MSC-2504877, 3- (4- (2-Hydroxypropan-2-yl) phenyl) -6-methylpyrrolo[1,2-a]pyrazin-1 (2H) -one, Tankyrase
Field of Research
Epigenetics & Chromatin, Molecular Biology
Purity
97.83% (May vary between batches)
Solubility
DMSO:3.6 mg/mL (12.75 mM)
Smiles
Cc1ccc2n1cc ([nH]c2=O) -c1ccc (cc1) C (C) (C) O
Molecular Formula
C17H18N2O2
Molecular Weight
282.34
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

3-(4-(2-Hydroxypropan-2-yl)phenyl)-6-methylpyrrolo[1,2-a]pyrazin-1(2H)-one
CAS Number1460286-21-8
PubChem CID71765184
IUPAC Name3-[4-(2-hydroxypropan-2-yl)phenyl]-6-methyl-2H-pyrrolo[1,2-a]pyrazin-1-one
Molecular FormulaC17H18N2O2
Molecular Weight282.34
XLogP1.9
Topological Polar Surface Area54.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Heavy Atom Count21
Formal Charge0
Complexity450
SMILES
CC1=CC=C2N1C=C(NC2=O)C3=CC=C(C=C3)C(C)(C)O
InChI
InChI=1S/C17H18N2O2/c1-11-4-9-15-16(20)18-14(10-19(11)15)12-5-7-13(8-6-12)17(2,3)21/h4-10,21H,1-3H3,(H,18,20)
InChIKey
MPXAEYSGFKRDQM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-(4-(2-Hydroxypropan-2-yl)phenyl)-6-methylpyrrolo[1,2-a]pyrazin-1(2H)-one
CAS: 1460286-21-8
CID: 71765184
Formula: C17H18N2O2
MW: 282.34
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight282.34
XLogP31.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass282.136827821
Monoisotopic Mass282.136827821
Topological Polar Surface Area54.3 Ų
Heavy Atom Count21
Formal Charge0
Complexity450
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA4380-5MSC2504877

Popular Products