Products for Research Use Only
RegisterLogin

LY-411575

CAT: 0013-GTR19171779-01Size: 2 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19171779-01Size:2 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
LY-411575 is a potent and selective γ-secretase inhibitor, demonstrating low nanomolar IC50 values in both membrane and cell-based assays for suppressing Notch cleavage. It is widely used in vitro and in vivo to investigate the Notch signaling pathway in cancer, neurology, and developmental biology research.
CAS Number
209984-57-6
Product Name Alternative
Apoptosis, Inhibitor, Gammasecretase, Gamma secretase, inhibit, Notch S3 cleavage, Notch, LY411575, LY-411575, LY 411575, γ secretase (cell-based), γ secretase (membrane-based), γ-secretase
Field of Research
Cell Biology, Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology
Purity
97.03% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.88 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:35.71 mg/mL (74.48 mM) ; Ethanol:11 mg/mL (22.94 mM)
Smiles
C[C@H] (NC (=O) [C@@H] (O) c1cc (F) cc (F) c1) C (=O) N[C@H]1c2ccccc2-c2ccccc2N (C) C1=O
Molecular Formula
C26H23F2N3O4
Molecular Weight
479.48
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(alphaS)-N-((1S)-2-(((7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz(b,d)azepin-7-yl)amino)-1-methyl-2-oxoethyl)-3,5-difluoro-alpha-hydroxybenzeneacetamide

LY-411575 is a dibenzoazepine that is 5,7-dihydro-6H-dibenzo[b,d]azepin-6-one which is substituted at the 7 pro-S position by the C-terminal carboxamide nitrogen of N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-L-alaninamide. It is a potent, cell permeable and selective gamma-secretase inhibitor. It has been tested as a possible treatment for Alzheimer's disease and shows promise for its potential to counteract severe hearing loss. It has a role as an EC 3.4.23.46 (memapsin 2) inhibitor. It is a lactam, a secondary alcohol, a difluorobenzene and a dibenzoazepine.

CAS Number209984-57-6
PubChem CID10435235
IUPAC Name(2S)-2-[[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide
Molecular FormulaC26H23F2N3O4
Molecular Weight479.5
XLogP3
Topological Polar Surface Area98.7
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Heavy Atom Count35
Formal Charge0
Complexity789
SMILES
C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)[C@H](C4=CC(=CC(=C4)F)F)O
InChI
InChI=1S/C26H23F2N3O4/c1-14(29-25(34)23(32)15-11-16(27)13-17(28)12-15)24(33)30-22-20-9-4-3-7-18(20)19-8-5-6-10-21(19)31(2)26(22)35/h3-14,22-23,32H,1-2H3,(H,29,34)(H,30,33)/t14-,22-,23-/m0/s1
InChIKey
ULSSJYNJIZWPSB-CVRXJBIPSA-N
Chemical Structure
2D Structure
2D structure of (alphaS)-N-((1S)-2-(((7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz(b,d)azepin-7-yl)amino)-1-methyl-2-oxoethyl)-3,5-difluoro-alpha-hydroxybenzeneacetamide
CAS: 209984-57-6
CID: 10435235
Formula: C26H23F2N3O4
MW: 479.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight479.5
XLogP33
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass479.16566255
Monoisotopic Mass479.16566255
Topological Polar Surface Area98.7 Ų
Heavy Atom Count35
Formal Charge0
Complexity789
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR18399324-01Mouse Ly-6G/Ly-6C Antibody
GTR19224347-01LY 135114
GTR19205482-01LY 222306
GTR19201156-01LY-311727
GTR19198922-01LY 288601
GTR19198921-01LY 81067
GTR19197226-01LY 134046
GTR19197211-01LY 186126
GTR19197209-01LY 189332
GTR19197205-01LY 201409

Alternative Products

CatalogName
366898LY-411575 (LY 411575, LY411575, Semagacestat)
MBS385100-01LY-411575
FL104120-01LY 411575
A11176-100LY-411575 100mg
A11176-25LY-411575 25mg
A11176-50LY-411575 50mg
A11176-10LY-411575 10mg
A11176-5LY-411575 5mg
A11176-2LY-411575 2mg
T11905-01LY-411575 isomer 3

Popular Products