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KPT276

CAT: 0013-GTR19171770-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19171770-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KPT276 is an orally active, selective inhibitor of nuclear export (SINE) that covalently and irreversibly binds to CRM1. It is used in preclinical research to study CRM1 inhibition in cancer models, demonstrating activity in both in vitro cell assays and in vivo xenograft studies.
CAS Number
1421919-75-6
Product Name Alternative
CRM1, KPT276, KPT-276, KPT 276
Field of Research
Pharmacology & Drug Discovery
Purity
99.84% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:11 mg/mL (25.81 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.69 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
FC (F) (F) c1cc (cc (c1) C (F) (F) F) -c1ncn (C=CC (=O) N2CC (F) (F) C2) n1
Molecular Formula
C16H10F8N4O
Molecular Weight
426.26
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one

KPT-276 is an organic molecular entity. It has a role as an exportin 1 inhibitor.

CAS Number1421919-75-6
PubChem CID71496742
IUPAC Name(Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one
Molecular FormulaC16H10F8N4O
Molecular Weight426.26
XLogP3.6
Topological Polar Surface Area51
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count11
Rotatable Bond Count3
Heavy Atom Count29
Formal Charge0
Complexity620
SMILES
C1C(CN1C(=O)/C=C\N2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)(F)F
InChI
InChI=1S/C16H10F8N4O/c17-14(18)6-27(7-14)12(29)1-2-28-8-25-13(26-28)9-3-10(15(19,20)21)5-11(4-9)16(22,23)24/h1-5,8H,6-7H2/b2-1-
InChIKey
JCHAWRDHMUSLMM-UPHRSURJSA-N
Chemical Structure
2D Structure
2D structure of (Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one
CAS: 1421919-75-6
CID: 71496742
Formula: C16H10F8N4O
MW: 426.26
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight426.26
XLogP33.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count11
Rotatable Bond Count3
Exact Mass426.07268625
Monoisotopic Mass426.07268625
Topological Polar Surface Area51 Ų
Heavy Atom Count29
Formal Charge0
Complexity620
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
MBS3841592-01KPT276
A16341-50KPT276 50mg
A16341-5KPT276 5mg
A16341-25KPT276 25mg
A16341-10KPT276 10mg
A16341-10mM-DKPT276 10mM * 1mL in DMSO

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