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Forskolin

CAT: 0013-GTR19171768-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19171768-02Size:50 mg
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Description
Forskolin is a labdane diterpene that activates adenylate cyclase (EC50=0.5 μM), elevating intracellular cAMP. This activity underpins its broad research use in studying cardiac inotropy, platelet aggregation, hypertension, and nuclear receptor (PXR/FXR) signaling in both cellular and animal models.
CAS Number
66575-29-9
Product Name Alternative
Coleonol
Field of Research
Cell Biology, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
Adenylate cyclase activator
Form
Powder
Solubility
Soluble in DMSO (up to 10 mg/ml) .
Smiles
O[C@@]12[C@]3 (C) [C@@] ([C@H] (O) [C@H] (OC (C) =O) [C@@]1 (C) O[C@] (C=C) (C) CC2=O) (C (C) (C) CC[C@@H]3O) [H]
Molecular Formula
C22H34O7
Molecular Weight
410.5
Storage Conditions
RT
Notes
For research use only.
Other Product Names
7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one

Chemical Information

Forskolin

Forskolin is a labdane diterpenoid isolated from the Indian Coleus plant. It has a role as an antihypertensive agent, a platelet aggregation inhibitor, an anti-HIV agent, a plant metabolite, a protein kinase A agonist and an adenylate cyclase agonist. It is a tertiary alpha-hydroxy ketone, an organic heterotricyclic compound, a triol, a labdane diterpenoid, a cyclic ketone and an acetate ester.

CAS Number66575-29-9
PubChem CID47936
IUPAC Name[(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate
Molecular FormulaC22H34O7
Molecular Weight410.5
XLogP1
Topological Polar Surface Area113
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Heavy Atom Count29
Formal Charge0
Complexity747
SMILES
CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O
InChI
InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1
InChIKey
OHCQJHSOBUTRHG-KGGHGJDLSA-N
Chemical Structure
2D Structure
2D structure of Forskolin
CAS: 66575-29-9
CID: 47936
Formula: C22H34O7
MW: 410.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight410.5
XLogP31
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass410.23045342
Monoisotopic Mass410.23045342
Topological Polar Surface Area113 Ų
Heavy Atom Count29
Formal Charge0
Complexity747
Isotope Atom Count0
Defined Atom Stereocenter Count8
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
326769Forskolin

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