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BMY 7378 dihydrochloride

CAT: 0013-GTR19171519-01Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19171519-01Size:1 ml x 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BMY 7378 dihydrochloride is a selective α1D-adrenergic receptor antagonist and a weak partial agonist at the 5-HT1A receptor. This compound is utilized in research to investigate adrenergic and serotonergic systems in cardiovascular and neurological studies, both in vitro and in vivo.
CAS Number
21102-95-4
Product Name Alternative
Adrenergic Receptor, AdrenergicReceptor, alpha 1-adrenoceptor, 5-HT1A, 5-HT1A receptor, 5-HT1C, 5-HT Receptor, 5HT Receptor, 5-hydroxytryptamine Receptor, 5HTReceptor, BMY 7378, BMY 7378 dihydrochloride, BMY 7378 Dihydrochloride, BMY7378, BMY-7378, BMY7378 Dihydrochloride, BMY-7378 Dihydrochloride, BMY7378 HCl, Dopamine Receptor, DopamineReceptor, D2, Beta Receptor, inhibit, Inhibitor, selective, Serotonin Receptor, spontaneously hypertensive rats, α2C-adrenoceptor, α1D-adrenoceptor
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
97.32% (May vary between batches)
Solubility
DMSO:85 mg/mL (185.42 mM) ; Ethanol:16 mg/mL (34.9 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.91 mM) ; H2O:84 mg/mL (183.24 mM)
Smiles
Cl.COc1ccccc1N1CCN (CCN2C (=O) CC3 (CCCC3) CC2=O) CC1.Cl
Molecular Formula
C22H33Cl2N3O3
Molecular Weight
458.42
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Bmy-7378
CAS Number21102-95-4
PubChem CID210172
IUPAC Name8-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-8-azaspiro[4.5]decane-7,9-dione;dihydrochloride
Molecular FormulaC22H33Cl2N3O3
Molecular Weight458.4
Topological Polar Surface Area53.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count30
Formal Charge0
Complexity547
SMILES
COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)CC4(CCCC4)CC3=O.Cl.Cl
InChI
InChI=1S/C22H31N3O3.2ClH/c1-28-19-7-3-2-6-18(19)24-13-10-23(11-14-24)12-15-25-20(26)16-22(17-21(25)27)8-4-5-9-22;;/h2-3,6-7H,4-5,8-17H2,1H3;2*1H
InChIKey
NIBOMXUDFLRHRV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Bmy-7378
CAS: 21102-95-4
CID: 210172
Formula: C22H33Cl2N3O3
MW: 458.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight458.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass457.1898973
Monoisotopic Mass457.1898973
Topological Polar Surface Area53.1 Ų
Heavy Atom Count30
Formal Charge0
Complexity547
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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