Trilobatin

CAT: 0013-GTR19171185-04Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19171185-04Size:10 mg

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Description

Trilobatin is a natural small molecule with antioxidant, anti-inflammatory, and anti-hyperglycemic properties. It functions by enhancing SOD activity, inhibiting the NF-κB pathway in response to LPS, and blocking α-glucosidase and α-amylase enzymes. This profile supports its research use in metabolic and inflammatory disease models, both in vitro and in vivo.

CAS Number

4192-90-9

Product Name Alternative

α-Amylase, Trilobatin, Sodium-dependent glucose cotransporters, TNF-α, SGLT, Sirt3, P-Phlorizin, Anti-tumor, AMPK, Inhibitor, HIV, entry, envelope, Human immunodeficiency virus, gp41, inhibit, Nrf2, PC12

Field of Research

Cell Biology, Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry

Purity

97.16% (May vary between batches)

Solubility

DMSO:240 mg/mL (549.94 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.58 mM) ; Ethanol:Soluble

Smiles

OC[C@H]1O[C@@H] (Oc2cc (O) c (C (=O) CCc3ccc (O) cc3) c (O) c2) [C@H] (O) [C@@H] (O) [C@@H]1O

Molecular Formula

C21H24O10

Molecular Weight

436.41

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

Trilobatin

Trilobatin is an aryl beta-D-glucoside that is phloretin attached to a beta-D-glucopyranosyl residue at position 4' via a glycosidic linkage. It is isolated from the leaves of the Chinese sweet tea Lithocarpus polystachyus and exhibits significant anti-hyperglycemic, anti-oxidative and anti-inflammatory properties. It has a role as an antioxidant, a sweetening agent, an anti-inflammatory agent and a plant metabolite. It is an aryl beta-D-glucoside, a monosaccharide derivative and a member of dihydrochalcones. It is functionally related to a phloretin.

CAS Number	4192-90-9
PubChem CID	6451798
IUPAC Name	1-[2,6-dihydroxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-(4-hydroxyphenyl)propan-1-one
Molecular Formula	C21H24O10
Molecular Weight	436.4
XLogP	1.2
Topological Polar Surface Area	177
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	7
Heavy Atom Count	31
Formal Charge	0
Complexity	569

SMILES

C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O)O

InChI

InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-12-7-14(25)17(15(26)8-12)13(24)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-23,25-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1

InChIKey

GSTCPEBQYSOEHV-QNDFHXLGSA-N

Chemical Structure

2D Structure

CAS: 4192-90-9

CID: 6451798

Formula: C21H24O10

MW: 436.4

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	436.4
XLogP3	1.2
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	7
Exact Mass	436.13694696
Monoisotopic Mass	436.13694696
Topological Polar Surface Area	177 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	569
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
BA1913-1	Trilobatin
HY-N4100R	Trilobatin (Standard)
XAB85382-01	Trilobatin 2''-acetate

Trilobatin

Chemical Information

Alternative Products

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