Cobimetinib

CAT: 0013-GTR19171077-01Size: 500 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19171077-01Size:500 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Cobimetinib (GDC-0973) is a potent and selective oral MEK1 inhibitor (IC50=4.2 nM) . It demonstrates antitumor efficacy by suppressing proliferation and promoting apoptosis in tumor cells, as validated in both cellular assays and in vivo xenograft models for cancer research.

CAS Number

934660-93-2

Product Name Alternative

XL 518, XL518, XL-518, RG 7420, RG7420, RG-7420, Mitogen-activated protein kinase kinase, inhibit, Inhibitor, GDC 0973, GDC0973, GDC-0973, MAP2K, MEK1, MEK, MAPKK, Apoptosis, Cobimetinib

Field of Research

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Purity

98.00% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.76 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:44 mg/mL (82.81 mM) ; DMSO:84.17 mg/mL (158.42 mM)

Smiles

C (=O) (C1=C (NC2=C (F) C=C (I) C=C2) C (F) =C (F) C=C1) N3C[C@] (O) (C3) [C@@H]4CCCCN4

Molecular Formula

C21H21F3IN3O2

Molecular Weight

531.31

Storage Conditions

-20°C

Notes

For research use only.

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Catalog	Name
T3623-01	Cobimetinib
A3322-5	Cobimetinib (racemate)
HY-13064A-01	Cobimetinib (hemifumarate)
AR-C03411-01	Cobimetinib-d9
FC157419-01	Cobimetinib fumarate
MBS5806837	Cobimetinib hemifumarate
FX28741-01	(R) -Cobimetinib

Cobimetinib

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