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GDC0084

CAT: 0013-GTR19170955-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19170955-01Size:2 mg
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Description
GDC-0084 (RG7666) is a selective PI3K inhibitor that blocks the PI3K/AKT signaling pathway, suppressing tumor cell proliferation and survival. It is utilized in oncology research for studying pathway biology and has demonstrated antitumor activity in both in vitro assays and in vivo xenograft models.
CAS Number
1382979-44-3
Product Name Alternative
GDC 0084, GDC0084, GDC-0084, mTOR, Paxalisib, RG 7666, RG7666, RG-7666, PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ
Field of Research
Signal Transduction
Purity
≥95% (May vary between batches)
Solubility
Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:3.83 mg/mL (10.02 mM)
Smiles
CC1 (C) OCCn2c1nc1c (nc (nc21) -c1cnc (N) nc1) N1CCOCC1
Molecular Formula
C18H22N8O2
Molecular Weight
382.42
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Paxalisib

GDC-0084 is under investigation in clinical trial NCT03696355 (Study of GDC-0084 in Pediatric Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma or Diffuse Midline Gliomas).

CAS Number1382979-44-3
PubChem CID57384863
IUPAC Name5-(6,6-dimethyl-4-morpholin-4-yl-8,9-dihydropurino[8,9-c][1,4]oxazin-2-yl)pyrimidin-2-amine
Molecular FormulaC18H22N8O2
Molecular Weight382.4
XLogP-0.3
Topological Polar Surface Area117
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count2
Heavy Atom Count28
Formal Charge0
Complexity552
SMILES
CC1(C2=NC3=C(N2CCO1)N=C(N=C3N4CCOCC4)C5=CN=C(N=C5)N)C
InChI
InChI=1S/C18H22N8O2/c1-18(2)16-22-12-14(25-3-6-27-7-4-25)23-13(11-9-20-17(19)21-10-11)24-15(12)26(16)5-8-28-18/h9-10H,3-8H2,1-2H3,(H2,19,20,21)
InChIKey
LGWACEZVCMBSKW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Paxalisib
CAS: 1382979-44-3
CID: 57384863
Formula: C18H22N8O2
MW: 382.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight382.4
XLogP3-0.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count2
Exact Mass382.18657197
Monoisotopic Mass382.18657197
Topological Polar Surface Area117 Ų
Heavy Atom Count28
Formal Charge0
Complexity552
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BUP13043-01GDC0084
MBS131429GDC-0084 (GDC0084; GDC 0084; RG7666; RG-7666; RG 7666)

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