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CAY10781

CAT: 0013-GTR19170901-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19170901-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CAY10781 is a small molecule inhibitor that disrupts the NRP-1/VEGF-A interaction, showing 43% inhibition at 12.5 μM. This compound also reduces VEGF-A-induced VEGFR2 phosphorylation in differentiated CAD cells, making it a useful research tool for studying angiogenesis in cancer and vascular biology models.
CAS Number
1210360-87-4
Product Name Alternative
CAY10781, CAY-10781, CAY 10781
Field of Research
Cardiovascular Research, Signal Transduction
Purity
98.69% (May vary between batches)
Solubility
Ethanol:Insoluble; DMF:Insoluble; PBS (pH 7.2) :Insoluble; DMSO:10 mg/mL (43.25 mM)
Smiles
OC (=O) CC1=CNC (=NC1=O) C1=CN=CC=C1
Molecular Formula
C11H9N3O3
Molecular Weight
231.21
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

2-(6-Oxo-2-(pyridin-3-yl)-1,6-dihydropyrimidin-5-yl)acetic acid
CAS Number1210360-87-4
PubChem CID45490125
IUPAC Name2-(6-oxo-2-pyridin-3-yl-1H-pyrimidin-5-yl)acetic acid
Molecular FormulaC11H9N3O3
Molecular Weight231.21
XLogP-0.7
Topological Polar Surface Area91.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count17
Formal Charge0
Complexity401
SMILES
C1=CC(=CN=C1)C2=NC=C(C(=O)N2)CC(=O)O
InChI
InChI=1S/C11H9N3O3/c15-9(16)4-8-6-13-10(14-11(8)17)7-2-1-3-12-5-7/h1-3,5-6H,4H2,(H,15,16)(H,13,14,17)
InChIKey
PQXHMOPMDOFJHD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(6-Oxo-2-(pyridin-3-yl)-1,6-dihydropyrimidin-5-yl)acetic acid
CAS: 1210360-87-4
CID: 45490125
Formula: C11H9N3O3
MW: 231.21
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight231.21
XLogP3-0.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass231.06439116
Monoisotopic Mass231.06439116
Topological Polar Surface Area91.7 Ų
Heavy Atom Count17
Formal Charge0
Complexity401
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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