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Arglabin

CAT: 0804-HY-16059-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16059-01Size:1 mg
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Description
Arglabin ((+) -Arglabin), a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor. Arglabin shows anti-inflammatory and antitumor activities[1]. The antitumor activity of Arglabin proceeds through its inhibition of farnesyl transferase which leads to the activation of RAS proto-oncogene[2].
CAS Number
84692-91-1
Product Name Alternative
(+) -Arglabin
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Farnesyl Transferase; NOD-like Receptor (NLR)
Type
Natural Products
Related Pathways
Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Arglabin.html
Purity
99.87
Solubility
DMSO : ≥ 100 mg/mL
Smiles
C[C@]1(CC[C@](C2=C)([H])[C@@](OC2=O)([H])[C@@]3([H])C(C)=CC4)[C@]34O1
Molecular Formula
C15H18O3
Molecular Weight
246.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Abderrazak A, et al. Anti-inflammatory and antiatherogenic effects of the NLRP3 inflammasome inhibitor arglabin in ApoE2.Ki mice fed a high-fat diet. Circulation. 2015;131 (12) :1061-1070.|[2]Lone SH, et al. Arglabin: From isolation to antitumor evaluation. Chem Biol Interact. 2015;240:180-198.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
NLRP3

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