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Afatinib Dimaleate

CAT: 0013-GTR19177701-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19177701-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Afatinib Dimaleate is an orally active, irreversible inhibitor of the ErbB (EGFR) family of receptor tyrosine kinases. This small molecule is used in research to study oncogenic signaling and has demonstrated antitumor activity in both cellular assays and animal models of non-small cell lung cancer and other solid tumors.
CAS Number
850140-73-7
Product Name Alternative
Inhibit, NCI-H1975, NIH-3T3 cells, NSCLC, orally active, lung cancer, HER2, HER1, Inhibitor, HKESC-1, HKESC-2, H1666, H3255, EGFR (L858R/T790M), EGFR (L858R), EGFR (wt), EC-1, EGFR, ErbB-1, Epidermal growth factor receptor, ESCC, Autophagy, Apoptosis, anticancer, BIBW 2992, BIBW 2992MA2, BIBW2992, BIBW-2992, A431, Afatinib Dimaleate, Afatinib, Afatinib (BIBW2992), Afatinib (BIBW2992) Dimaleate, Akt, c-Met/HGFR, SLMT-1, Protein kinase B, PKB, p38 MAPK
Field of Research
Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.11% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:252 mg/mL (350.94 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
OC (=O) \C=C/C (O) =O.OC (=O) \C=C/C (O) =O.CN (C) C\C=C\C (=O) Nc1cc2c (Nc3ccc (F) c (Cl) c3) ncnc2cc1O[C@H]1CCOC1
Molecular Formula
C32H33ClFN5O11
Molecular Weight
718.08
Storage Conditions
-20°C
Notes
For research use only.

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