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GNE-1858

CAT: 0013-GTR19177306-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19177306-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GNE-1858 is a potent and selective ATP-competitive inhibitor of hematopoietic progenitor kinase 1 (HPK1), demonstrating low nanomolar IC50 values against the wild-type and active mimetic mutant forms. This small molecule is a valuable research tool for investigating HPK1's role in immune cell signaling and T-cell function in both cellular and animal models of oncology and immunotherapy.
CAS Number
2680616-96-8
Product Name Alternative
GNE 1858, GNE1858, GNE-1858, Inhibitor, hematopoietic, MAP4K, MAPK Kinase Kinase Kinase, HPK1, inhibit, negative-feedback, regulator, proliferation, progenitor, signaling, receptor, T-cell
Field of Research
Signal Transduction
Purity
98.70% (May vary between batches)
Solubility
DMSO:4.29 mg/mL (10.01 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.33 mM)
Smiles
CC (C) n1ncc2cnc (Nc3cc (nc (n3) N3CCC (F) (F) C3) C3CCNC3) cc12
Molecular Formula
C21H26F2N8
Molecular Weight
428.48
Storage Conditions
-20°C
Notes
For research use only.

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