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Diosmetin

CAT: 0013-GTR19174096-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174096-02Size:50 mg
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Description
Diosmetin, a methylated derivative of luteolin, exhibits weak agonist activity at the TrkB receptor. This small molecule is utilized in neuroscience research to study neurotrophic signaling pathways in both cellular and animal models of neuronal survival and plasticity.
CAS Number
520-34-3
Product Name Alternative
Trkreceptor, TrkB, Trk receptor, Inhibitor, inhibit, Luteolin 4-methyl ether, Cytochrome P450, CYP1A1, CYPs, Diosmetin
Field of Research
Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.00% (May vary between batches)
Solubility
DMSO:39 mg/mL (129.89 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.66 mM)
Smiles
O=C1C=2C (OC (=C1) C3=CC (O) =C (OC) C=C3) =CC (O) =CC2O
Molecular Formula
C16H12O6
Molecular Weight
300.26
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Diosmetin

Diosmetin is a monomethoxyflavone that is the 4'-methyl ether derivative of luteolin. It is a natural product isolated from citrus fruits which exhibits a range of pharmacological activities. It has a role as a tropomyosin-related kinase B receptor agonist, an antioxidant, an antineoplastic agent, a vasodilator agent, an angiogenesis inhibitor, a bone density conservation agent, an anti-inflammatory agent, an apoptosis inducer, a plant metabolite and a cardioprotective agent. It is a monomethoxyflavone, a trihydroxyflavone and a 3'-hydroxyflavonoid. It is functionally related to a luteolin. It is a conjugate acid of a diosmetin-7-olate.

CAS Number520-34-3
PubChem CID5281612
IUPAC Name5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one
Molecular FormulaC16H12O6
Molecular Weight300.26
XLogP1.7
Topological Polar Surface Area96.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Heavy Atom Count22
Formal Charge0
Complexity462
SMILES
COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O
InChI
InChI=1S/C16H12O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-7,17-19H,1H3
InChIKey
MBNGWHIJMBWFHU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Diosmetin
CAS: 520-34-3
CID: 5281612
Formula: C16H12O6
MW: 300.26
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight300.26
XLogP31.7
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass300.06338810
Monoisotopic Mass300.06338810
Topological Polar Surface Area96.2 Ų
Heavy Atom Count22
Formal Charge0
Complexity462
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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