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Tirofiban

CAT: 0013-GTR19171666-06Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19171666-06Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tirofiban (L700462, MK-383) is a potent and selective antagonist of the platelet GPIIb/IIIa receptor, inhibiting aggregation with an IC50 of 9 nM. It is widely used in cardiovascular research to study thrombosis and has been applied in both in vitro platelet function assays and in vivo models of arterial injury.
CAS Number
144494-65-5
Product Name Alternative
Antithrombotic, AMI, Aggrastat, ACSs, Integrin, Inhibitor, HUVEC, L700462, L-700462, GPIIb/IIIa, HAEC, inhibit, L 700462, MK 383, MK383, MK-383, Tirofiban, VEGF
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Purity
99.83% (May vary between batches)
Solubility
1M HCL:54 mg/mL (122.56 mM) ; DMSO:< 1 mg/mL (insoluble or slightly soluble) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
CCCCS (=O) (=O) N[C@@H] (Cc1ccc (OCCCCC2CCNCC2) cc1) C (O) =O
Molecular Formula
C22H36N2O5S
Molecular Weight
440.6
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Tirofiban

Tirofiban is a member of the class of piperidines that is L-tyrosine in which a hydrogen attached to the amino group is replaced by a butylsulfonyl group and in which the hydrogen attached to the phenolic hydroxy group is replaced by a 4-(piperidin-4-yl)butyl group. It has a role as a fibrin modulating drug, an anticoagulant and a platelet glycoprotein-IIb/IIIa receptor antagonist. It is a member of piperidines, a L-tyrosine derivative and a sulfonamide.

CAS Number144494-65-5
PubChem CID60947
IUPAC Name(2S)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-ylbutoxy)phenyl]propanoic acid
Molecular FormulaC22H36N2O5S
Molecular Weight440.6
XLogP1.4
Topological Polar Surface Area113
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count14
Heavy Atom Count30
Formal Charge0
Complexity579
SMILES
CCCCS(=O)(=O)N[C@@H](CC1=CC=C(C=C1)OCCCCC2CCNCC2)C(=O)O
InChI
InChI=1S/C22H36N2O5S/c1-2-3-16-30(27,28)24-21(22(25)26)17-19-7-9-20(10-8-19)29-15-5-4-6-18-11-13-23-14-12-18/h7-10,18,21,23-24H,2-6,11-17H2,1H3,(H,25,26)/t21-/m0/s1
InChIKey
COKMIXFXJJXBQG-NRFANRHFSA-N
Chemical Structure
2D Structure
2D structure of Tirofiban
CAS: 144494-65-5
CID: 60947
Formula: C22H36N2O5S
MW: 440.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight440.6
XLogP31.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count14
Exact Mass440.23449343
Monoisotopic Mass440.23449343
Topological Polar Surface Area113 Ų
Heavy Atom Count30
Formal Charge0
Complexity579
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
FT142225-01Tirofiban
RM-T180699-01Tirofiban Impurity 99; Tirofiban Impurity W
HY-17369ATirofiban (hydrochloride)
RM-T180600-01Tirofiban Hcl
RM-T180627-01(R) -Tirofiban

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