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Astragaloside IV

CAT: 0013-GTR19171294-07Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19171294-07Size:500 mg
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Description
Astragaloside IV is a bioactive saponin from Astragalus membranaceus with broad research applications. It exhibits anti-cancer activity in vitro by inhibiting ERK/JNK signaling and MMPs in MDA-MB-231 cells, and demonstrates cardioprotective effects in vivo, reducing infarct size in canine models. It also shows antiviral activity against HAdV-3 replication in A549 cells.
CAS Number
84687-43-4
Product Name Alternative
AS-IV, Astragaloside IV, AST-IV, Matrix metalloproteinases, ERS, ERK, Extracellular signal regulated kinases, Estrogen Receptor, EstrogenReceptor, MMP, Inhibitor, inhibit, JNK, progestogen Receptor, progestogenReceptor
Field of Research
Metabolism Research, Protein Biochemistry, Signal Transduction
Purity
98.85% (May vary between batches)
Solubility
DMSO:100 mg/mL (127.39 mM)
Smiles
CC (C) (O) [C@@H]1CC[C@@] (C) (O1) [C@H]1[C@H] (O) C[C@@]2 (C) C3C[C@@H] (O[C@@H]4O[C@H] (CO) [C@@H] (O) [C@H] (O) [C@H]4O) C4[C@]5 (CC35CC[C@]12C) CCC (O[C@@H]1OC[C@@H] (O) [C@H] (O) [C@H]1O) C4 (C) C
Molecular Formula
C41H68O14
Molecular Weight
784.97
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Astragaloside IV

Astragaloside IV is a pentacyclic triterpenoid that is cycloastragenol having beta-D-xylopyranosyl and beta-D-glucopyranosyl residues attached at positions O-3 and O-6 respectively. It is isolated from Astragalus membranaceus var mongholicus. It has a role as an antioxidant, an EC 4.2.1.1 (carbonic anhydrase) inhibitor, a neuroprotective agent, an anti-inflammatory agent, a pro-angiogenic agent and a plant metabolite. It is a pentacyclic triterpenoid and a triterpenoid saponin. It is functionally related to a cycloastragenol.

CAS Number84687-43-4
PubChem CID13943297
IUPAC Name(2R,3R,4S,5S,6R)-2-[[(1S,3R,6S,8R,9S,11S,12S,14S,15R,16R)-14-hydroxy-15-[(2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl]-7,7,12,16-tetramethyl-6-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxy-9-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
Molecular FormulaC41H68O14
Molecular Weight785.0
XLogP1.3
Topological Polar Surface Area228
Hydrogen Bond Donor Count9
Hydrogen Bond Acceptor Count14
Rotatable Bond Count7
Heavy Atom Count55
Formal Charge0
Complexity1460
SMILES
C[C@]12CC[C@@]34C[C@@]35CC[C@@H](C([C@@H]5[C@H](C[C@H]4[C@@]1(C[C@@H]([C@@H]2[C@]6(CC[C@H](O6)C(C)(C)O)C)O)C)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)(C)C)O[C@H]8[C@@H]([C@H]([C@@H](CO8)O)O)O
InChI
InChI=1S/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3/t19-,20+,21-,22+,23-,24-,25-,26-,27+,28-,29+,30+,31-,32-,33-,34+,37+,38-,39+,40-,41+/m0/s1
InChIKey
QMNWISYXSJWHRY-YLNUDOOFSA-N
Chemical Structure
2D Structure
2D structure of Astragaloside IV
CAS: 84687-43-4
CID: 13943297
Formula: C41H68O14
MW: 785.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight785.0
XLogP31.3
Hydrogen Bond Donor Count9
Hydrogen Bond Acceptor Count14
Rotatable Bond Count7
Exact Mass784.46090684
Monoisotopic Mass784.46090684
Topological Polar Surface Area228 Ų
Heavy Atom Count55
Formal Charge0
Complexity1460
Isotope Atom Count0
Defined Atom Stereocenter Count21
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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