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PF-04418948

CAT: 0013-GTR19173357-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19173357-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-04418948 is a highly selective and potent antagonist of the EP2 receptor (IC50 = 16 nM), demonstrating over 2000-fold selectivity against related prostanoid receptors. It effectively inhibits PGE2-induced cAMP signaling in vitro and reverses PGE2-mediated tracheal relaxation ex vivo (IC50 = 2.7 nM), making it a valuable tool for researching EP2 function in inflammation, smooth muscle physiology, and related disease models.
CAS Number
1078166-57-0
Product Name Alternative
CHO, inhibit, Inhibitor, orally activity, PF 04418948, PF04418948, PF-04418948, PGE2, ProstaglandinReceptor, Prostaglandin Receptor
Field of Research
Immunology & Inflammation, Pharmacology & Drug Discovery
Purity
97.61% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.89 mM) ; DMSO:45 mg/mL (109.91 mM)
Smiles
COc1ccc2cc (OCC3 (CN (C3) C (=O) c3ccc (F) cc3) C (O) =O) ccc2c1
Molecular Formula
C23H20FNO5
Molecular Weight
409.41
Storage Conditions
-20°C
Notes
For research use only.

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Alternative Products

CatalogName
B1168-5PF-04418948
4818/50PF 04418948
A12894-10PF-04418948 10mg
A12894-2PF-04418948 2mg
A12894-50PF-04418948 50mg
A12894-1PF-04418948 1mg
A12894-100PF-04418948 100mg
A12894-25PF-04418948 25mg

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