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ADX88178

CAT: 0013-GTR19170991-02Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19170991-02Size:1 ml x 10 mM (in DMSO)
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Description
ADX88178 is a highly potent and selective positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4), exhibiting an EC50 of 4 nM at the human receptor. This compound is a valuable research tool for investigating mGluR4 function in models of Parkinson's disease and other neurological disorders, supporting both in vitro and in vivo experimental applications.
CAS Number
1235318-89-4
Product Name Alternative
ADX 88178, ADX88178, ADX-88178, mGluR, mGluR4 (Human), Metabotropic glutamate receptors, inhibit, Inhibitor
Field of Research
Neuroscience
Purity
99.26% (May vary between batches)
Solubility
DMSO:22.5 mg/mL (82.62 mM) ;10% DMSO+90% Saline:1.5 mg/mL (5.51 mM)
Smiles
Cc1sc (Nc2nccc (C) n2) nc1-c1cn[nH]c1
Molecular Formula
C12H12N6S
Molecular Weight
272.33
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Adx88178
CAS Number1235318-89-4
PubChem CID46836872
IUPAC Name5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)-1,3-thiazol-2-amine
Molecular FormulaC12H12N6S
Molecular Weight272.33
XLogP2.2
Topological Polar Surface Area108
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count19
Formal Charge0
Complexity304
SMILES
CC1=NC(=NC=C1)NC2=NC(=C(S2)C)C3=CNN=C3
InChI
InChI=1S/C12H12N6S/c1-7-3-4-13-11(16-7)18-12-17-10(8(2)19-12)9-5-14-15-6-9/h3-6H,1-2H3,(H,14,15)(H,13,16,17,18)
InChIKey
MIQNXKWDQRNHAU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Adx88178
CAS: 1235318-89-4
CID: 46836872
Formula: C12H12N6S
MW: 272.33
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight272.33
XLogP32.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass272.08441558
Monoisotopic Mass272.08441558
Topological Polar Surface Area108 Ų
Heavy Atom Count19
Formal Charge0
Complexity304
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T4500-01ADX88178
A20922-200ADX88178 200mg
A20922-50ADX88178 50mg
A20922-100ADX88178 100mg
A20922-2ADX88178 2mg
A20922-5ADX88178 5mg
A20922-1ADX88178 1mg
A20922-25ADX88178 25mg
A20922-10ADX88178 10mg
A20922-10mM-DADX88178 10mM * 1mL in DMSO

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