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PFI-2 HCl (R-)

CAT: 0013-GTR19170525-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19170525-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PFI-2 hydrochloride is a potent and selective cell-active inhibitor of the SETD7 methyltransferase, exhibiting an IC50 of 2 nM. It is the (R) -enantiomer, showing 500-fold greater activity than its (S) -counterpart. This compound is a valuable chemical probe for studying lysine methylation in epigenetic regulation, cancer biology, and inflammation research in cellular and biochemical assays.
CAS Number
1627607-87-7
Product Name Alternative
Renal fibrosis, SETD7, SET domain containing lysine methyltransferase 7 (SETD7), PFI 2, PFI 2 Hydrochloride, PFI 2 hydrochloride, PFI2, PFI-2, PFI-2 HCl, PFI2 hydrochloride, PFI2 Hydrochloride, PFI-2 Hydrochloride, chronic kidney disease, (R) -PFI-2 hydrochloride, inflammation, inhibit, macrophage, Histone Methyltransferase, HistoneMethyltransferase, Inhibitor
Field of Research
Epigenetics & Chromatin, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
Methyltransferase SETD7 inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to at least 25 mg/ml)
Smiles
Cl.Fc1cc (cc2CCNCc12) S (=O) (=O) N[C@H] (Cc1cccc (c1) C (F) (F) F) C (=O) N1CCCC1
Molecular Formula
C23H25F4N3O3S HCl
Molecular Weight
535.98
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
(1R) -1-[[3- (Trifluoromethyl) phenyl]methyl]-2-oxo-2- (1-pyrrolidinyl) ethyl-1,2,3,4-tetrahydro-6-isoquinolinesulfonamide hydrochloride

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