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CCT241736

CAT: 0013-GTR19170229-05Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19170229-05Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CCT241736 is an orally active dual inhibitor of FLT3 and Aurora kinases, effective against resistant FLT3 mutants like ITD. This preclinical candidate shows potent activity in vitro and in vivo, supporting its development for acute myeloid leukemia (AML) in both adult and pediatric contexts.
CAS Number
1402709-93-6
Product Name Alternative
Inhibit, Inhibitor, FLT3, Fms like tyrosine kinase 3, Aurora Kinase, AuroraKinase, CCT241736, CCT-241736, CCT 241736, Cluster of differentiation antigen 135, CD135
Field of Research
Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction
Purity
96.20% (May vary between batches)
Solubility
H2O:< 0.1 mg/mL (insoluble) ;10% DMSO+90% Corn Oil:3.3 mg/mL (7.23 mM) ; DMSO:75 mg/mL (164.34 mM)
Smiles
Cc1nn (C) cc1-c1nc2c (N3CCN (Cc4ccc (Cl) cc4) CC3) c (Cl) cnc2[nH]1
Molecular Formula
C22H23Cl2N7
Molecular Weight
456.37
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

6-chloro-7-(4-(4-chlorobenzyl)piperazin-1-yl)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo(4,5-b)pyridine

Mobinitinib is an orally bioavailable inhibitor of both the serine/threonine protein kinase Aurora kinase and FMS-related tyrosine kinase 3 (FLT3; STK1; CD135; FLK2), with potential antineoplastic activity. Upon oral administration, mobinitinib specifically binds to and inhibits Aurora kinase and FLT3, which interferes with the activation of Aurora kinase- and FLT3-mediated signal transduction pathways. This may result in the disruption of the assembly of the mitotic spindle apparatus, the disruption of chromosome segregation and the inhibition of cell proliferation in tumor cells that overexpress Aurora kinase and/or FLT3. Aurora kinase plays essential roles in mitotic checkpoint control during mitosis. Aurora kinase and FLT3 are overexpressed in a variety of cancers and play key roles in tumor cell proliferation.

CAS Number1402709-93-6
PubChem CID71454279
IUPAC Name6-chloro-7-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]-2-(1,3-dimethylpyrazol-4-yl)-1H-imidazo[4,5-b]pyridine
Molecular FormulaC22H23Cl2N7
Molecular Weight456.4
XLogP3.8
Topological Polar Surface Area65.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count31
Formal Charge0
Complexity596
SMILES
CC1=NN(C=C1C2=NC3=NC=C(C(=C3N2)N4CCN(CC4)CC5=CC=C(C=C5)Cl)Cl)C
InChI
InChI=1S/C22H23Cl2N7/c1-14-17(13-29(2)28-14)21-26-19-20(18(24)11-25-22(19)27-21)31-9-7-30(8-10-31)12-15-3-5-16(23)6-4-15/h3-6,11,13H,7-10,12H2,1-2H3,(H,25,26,27)
InChIKey
AKJBLKUZXRMECW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 6-chloro-7-(4-(4-chlorobenzyl)piperazin-1-yl)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo(4,5-b)pyridine
CAS: 1402709-93-6
CID: 71454279
Formula: C22H23Cl2N7
MW: 456.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight456.4
XLogP33.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass455.1391992
Monoisotopic Mass455.1391992
Topological Polar Surface Area65.9 Ų
Heavy Atom Count31
Formal Charge0
Complexity596
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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