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ICRT 14

CAT: 0013-GTR19170180-05Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19170180-05Size:25 mg
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Description
ICRT 14 is a potent small-molecule inhibitor of β-catenin-dependent transcription, demonstrating an IC50 of 40.3 nM in Wnt pathway assays. It is a valuable research tool for studying Wnt/β-catenin signaling in cancer biology and stem cell research, applicable in both in vitro and in vivo experimental models.
CAS Number
677331-12-3
Product Name Alternative
Betacatenin, beta-catenin, bcatenin, Inhibitor, iCRT 14, iCRT14, iCRT-14, inhibit, Wnt/betacatenin, Wnt/b-catenin, Wnt, Wnt/β-catenin, βcatenin
Field of Research
Signal Transduction, Stem Cell & Developmental Biology
Purity
98.85% (May vary between batches)
Solubility
DMSO:12 mg/mL (31.96 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.33 mM)
Smiles
Cc1cc (C=C2SC (=O) N (C2=O) c2ccccc2) c (C) n1-c1cccnc1
Molecular Formula
C21H17N3O2S
Molecular Weight
375.44
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(5Z)-5-[(2,5-dimethyl-1-pyridin-3-ylpyrrol-3-yl)methylidene]-3-phenyl-1,3-thiazolidine-2,4-dione

ICRT14 is a member of thiazolidinediones. It has a role as a Wnt signalling inhibitor.

CAS Number677331-12-3
PubChem CID5967294
IUPAC Name(5Z)-5-[(2,5-dimethyl-1-pyridin-3-ylpyrrol-3-yl)methylidene]-3-phenyl-1,3-thiazolidine-2,4-dione
Molecular FormulaC21H17N3O2S
Molecular Weight375.4
XLogP4.1
Topological Polar Surface Area80.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count27
Formal Charge0
Complexity617
SMILES
CC1=CC(=C(N1C2=CN=CC=C2)C)/C=C\3/C(=O)N(C(=O)S3)C4=CC=CC=C4
InChI
InChI=1S/C21H17N3O2S/c1-14-11-16(15(2)23(14)18-9-6-10-22-13-18)12-19-20(25)24(21(26)27-19)17-7-4-3-5-8-17/h3-13H,1-2H3/b19-12-
InChIKey
NCSHZXNGQYSKLR-UNOMPAQXSA-N
Chemical Structure
2D Structure
2D structure of (5Z)-5-[(2,5-dimethyl-1-pyridin-3-ylpyrrol-3-yl)methylidene]-3-phenyl-1,3-thiazolidine-2,4-dione
CAS: 677331-12-3
CID: 5967294
Formula: C21H17N3O2S
MW: 375.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight375.4
XLogP34.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass375.10414797
Monoisotopic Mass375.10414797
Topological Polar Surface Area80.5 Ų
Heavy Atom Count27
Formal Charge0
Complexity617
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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