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Glasdegib

CAT: 0013-GTR19169856-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19169856-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Glasdegib (PF-04449913) is a potent, orally active Smoothened (Smo) antagonist with an IC50 of 5 nM. This small molecule inhibitor is used in research to study Hedgehog signaling pathway dysregulation in cancers, demonstrating activity in both in vitro assays and in vivo models.
CAS Number
1095173-27-5
Product Name Alternative
Smo, Smoothened, PF 04449913, PF04449913, PF-04449913, Inhibitor, inhibit, Glasdegib, Hedgehog
Field of Research
Pharmacology & Drug Discovery, Stem Cell & Developmental Biology
Purity
98.00% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.34 mM) ; DMSO:48 mg/mL (128.19 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
CN1CC[C@H] (C[C@@H]1c1nc2ccccc2[nH]1) NC (=O) Nc1ccc (cc1) C#N
Molecular Formula
C21H22N6O
Molecular Weight
374.44
Storage Conditions
-20°C
Notes
For research use only.

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HY-16391BGlasdegib (hydrochloride)
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