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ME-0328

CAT: 0013-GTR19169792-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19169792-02Size:25 mg
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Description
ME0328 is a potent small molecule inhibitor exhibiting high selectivity for PARP3, with an IC50 of 0.89 μM and approximately 7-fold selectivity over PARP1. This compound is a valuable chemical probe for investigating PARP3-specific functions in DNA repair pathways, supporting both in vitro biochemical assays and cellular mechanism-of-action studies.
CAS Number
1445251-22-8
Product Name Alternative
PARP, PARP3, PARP1, inhibit, Inhibitor, ME0328, ME-0328, ME 0328, poly ADP ribose polymerase
Field of Research
Epigenetics & Chromatin, Molecular Biology
Purity
>98%
Bioactivity
PARP3 inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 4 mg/ml with warming) .
Smiles
C[C@H] (NC (=O) CCc1nc2ccccc2c (=O) [nH]1) c1ccccc1
Molecular Formula
C19H19N3O2
Molecular Weight
321.38
Storage Conditions
RT
Notes
For research use only.
Other Product Names
3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[ (1S) -1-phenylethyl]-2-quinazolinepropanamide

Chemical Information

ME0328

inhibits ARTD3; structure in first source

CAS Number1445251-22-8
PubChem CID135566764
IUPAC Name3-(4-oxo-3H-quinazolin-2-yl)-N-[(1S)-1-phenylethyl]propanamide
Molecular FormulaC19H19N3O2
Molecular Weight321.4
XLogP1.8
Topological Polar Surface Area70.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Heavy Atom Count24
Formal Charge0
Complexity497
SMILES
C[C@@H](C1=CC=CC=C1)NC(=O)CCC2=NC3=CC=CC=C3C(=O)N2
InChI
InChI=1S/C19H19N3O2/c1-13(14-7-3-2-4-8-14)20-18(23)12-11-17-21-16-10-6-5-9-15(16)19(24)22-17/h2-10,13H,11-12H2,1H3,(H,20,23)(H,21,22,24)/t13-/m0/s1
InChIKey
QIHBWVVVRYYYRO-ZDUSSCGKSA-N
Chemical Structure
2D Structure
2D structure of ME0328
CAS: 1445251-22-8
CID: 135566764
Formula: C19H19N3O2
MW: 321.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight321.4
XLogP31.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass321.147726857
Monoisotopic Mass321.147726857
Topological Polar Surface Area70.6 Ų
Heavy Atom Count24
Formal Charge0
Complexity497
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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