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Verdiperstat

CAT: 0013-GTR19169710-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19169710-01Size:1 mg
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Description
Verdiperstat (AZD3241) is an orally bioavailable, irreversible, and selective myeloperoxidase inhibitor with an IC50 of 630 nM. It has been investigated in preclinical models for neurodegenerative diseases like Parkinson's and Alzheimer's, where MPO-mediated oxidative stress is implicated in pathology.
CAS Number
890655-80-8
Product Name Alternative
AZD 3241, AZD3241, AZD-3241, myeloperoxidase, inhibit, Inhibitor, GlutathionePeroxidase, Glutathione Peroxidase, Verdiperstat
Field of Research
Metabolism Research
Purity
99.16% (May vary between batches)
Solubility
DMSO:150 mg/mL (592.14 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (15.79 mM)
Smiles
CC (C) OCCn1c2cc[nH]c2c (=O) [nH]c1=S
Molecular Formula
C11H15N3O2S
Molecular Weight
253.32
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Verdiperstat

Verdiperstat has been used in trials studying the basic science and treatment of Multiple System Atrophy (MSA).

CAS Number890655-80-8
PubChem CID11528958
IUPAC Name1-(2-propan-2-yloxyethyl)-2-sulfanylidene-5H-pyrrolo[3,2-d]pyrimidin-4-one
Molecular FormulaC11H15N3O2S
Molecular Weight253.32
XLogP1
Topological Polar Surface Area89.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count17
Formal Charge0
Complexity322
SMILES
CC(C)OCCN1C2=C(C(=O)NC1=S)NC=C2
InChI
InChI=1S/C11H15N3O2S/c1-7(2)16-6-5-14-8-3-4-12-9(8)10(15)13-11(14)17/h3-4,7,12H,5-6H2,1-2H3,(H,13,15,17)
InChIKey
FVJCUZCRPIMVLB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Verdiperstat
CAS: 890655-80-8
CID: 11528958
Formula: C11H15N3O2S
MW: 253.32
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight253.32
XLogP31
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass253.08849790
Monoisotopic Mass253.08849790
Topological Polar Surface Area89.5 Ų
Heavy Atom Count17
Formal Charge0
Complexity322
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA3441-5.1Verdiperstat
A22041-50Verdiperstat 50mg
A22041-10Verdiperstat 10mg
A22041-5Verdiperstat 5mg
A22041-100Verdiperstat 100mg
A22041-2Verdiperstat (AZD3241) 2mg
A22041-1Verdiperstat (AZD3241) 1mg
A22041-25Verdiperstat (AZD3241) 25mg
A22041-10mM-DVerdiperstat (AZD3241) 10mM * 1mL in DMSO

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