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D-tetrahydropalmatine

CAT: 0013-GTR19169351-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19169351-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
D-Tetrahydropalmatine is a selective inhibitor of the organic cation transporter 1 (OCT1) . It effectively blocks monocrotaline (MCT) uptake in vitro, as demonstrated in MDCK-hOCT1 cells and primary rat hepatocytes, thereby reducing MCT-induced cytotoxicity. This makes it a valuable pharmacological tool for studying hepatic drug transport and toxin metabolism in experimental models.
CAS Number
3520-14-7
Product Name Alternative
Dopamine Receptor, Dopamine, DopamineReceptor, Dtetrahydropalmatine, D-tetrahydropalmatine, D-Tetrahydropalmatine, D tetrahydropalmatine, inhibit, Inhibitor
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
99.34% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.63 mM) ; DMSO:25 mg/mL (70.34 mM)
Smiles
[H][C@@]12Cc3ccc (OC) c (OC) c3CN1CCc1cc (OC) c (OC) cc21
Molecular Formula
C21H25NO4
Molecular Weight
355.43
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Tetrahydropalmatine, (+)-

D-Tetrahydropalmatine is an alkaloid.

CAS Number3520-14-7
PubChem CID969488
IUPAC Name(13aR)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline
Molecular FormulaC21H25NO4
Molecular Weight355.4
XLogP3.2
Topological Polar Surface Area40.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count26
Formal Charge0
Complexity475
SMILES
COC1=C(C2=C(C[C@@H]3C4=CC(=C(C=C4CCN3C2)OC)OC)C=C1)OC
InChI
InChI=1S/C21H25NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,10-11,17H,7-9,12H2,1-4H3/t17-/m1/s1
InChIKey
AEQDJSLRWYMAQI-QGZVFWFLSA-N
Chemical Structure
2D Structure
2D structure of Tetrahydropalmatine, (+)-
CAS: 3520-14-7
CID: 969488
Formula: C21H25NO4
MW: 355.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight355.4
XLogP33.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass355.17835828
Monoisotopic Mass355.17835828
Topological Polar Surface Area40.2 Ų
Heavy Atom Count26
Formal Charge0
Complexity475
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

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sc-473158D-Tetrahydropalmatine
T2793-01Tetrahydropalmatine
C11137-25mg(+/-) -tetrahydropalmatine
300142D-Tetrahydropalmatine discontinued. See 021574

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