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AS-8351

CAT: 0013-GTR19169148-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19169148-01Size:5 mg
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Description
AS8351 (NSC51355) is a histone demethylase inhibitor. It has been utilized in cellular reprogramming research, notably in combination with other small molecules to convert human fetal lung fibroblasts into cardiomyocyte-like cells in vitro, demonstrating its role in epigenetic regulation and cardiac regeneration studies.
CAS Number
796-42-9
Product Name Alternative
NSC-51355
Field of Research
Epigenetics & Chromatin, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
KDM5B histone demethylase inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 45 mg/ml), in DMF (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml with warming)
Smiles
NN (\C=C1/C (=O) C=Cc2ccccc12) C (=O) c1ccncc1
Molecular Formula
C17H13N3O2
Molecular Weight
291.3
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone

Chemical Information

(e)-n'-((2-Hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide
CAS Number796-42-9
PubChem CID135400486
IUPAC NameN-[(E)-(2-hydroxynaphthalen-1-yl)methylideneamino]pyridine-4-carboxamide
Molecular FormulaC17H13N3O2
Molecular Weight291.30
XLogP2.7
Topological Polar Surface Area74.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count22
Formal Charge0
Complexity407
SMILES
C1=CC=C2C(=C1)C=CC(=C2/C=N/NC(=O)C3=CC=NC=C3)O
InChI
InChI=1S/C17H13N3O2/c21-16-6-5-12-3-1-2-4-14(12)15(16)11-19-20-17(22)13-7-9-18-10-8-13/h1-11,21H,(H,20,22)/b19-11+
InChIKey
WQSHHAVECQJKLX-YBFXNURJSA-N
Chemical Structure
2D Structure
2D structure of (e)-n'-((2-Hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide
CAS: 796-42-9
CID: 135400486
Formula: C17H13N3O2
MW: 291.30
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight291.30
XLogP32.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass291.100776666
Monoisotopic Mass291.100776666
Topological Polar Surface Area74.6 Ų
Heavy Atom Count22
Formal Charge0
Complexity407
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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