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Betahistine

CAT: 0013-GTR19169054-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19169054-01Size:100 mg
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Description
Betahistine dihydrochloride is a histamine analog and H1 receptor agonist used as an anti-vertigo agent in Ménière's disease research. Its vasodilatory properties are also studied in models of vascular headaches, though it is contraindicated in asthma and ulcer research. In vitro studies investigate its receptor affinity, while in vivo models assess its efficacy in balance disorders.
CAS Number
5638-76-6
Product Name Alternative
Ménière, HistamineReceptor, Histamine Receptor, H1 receptor, episode, Inhibitor, inhibit, disease, Betahistine, CIA, antipsychotic, arthritis, Serc base, Rheumatoid, PT 9 base, schizophrenia, Vasomotal
Field of Research
Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery
Purity
97.92% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (14.69 mM) ; DMSO:30 mg/mL (220.28 mM)
Smiles
CNCCC1=NC=CC=C1
Molecular Formula
C8H12N2
Molecular Weight
136.19
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Betahistine

Betahistine is an aminoalkylpyridine that is pyridine substituted by a 2-(methylamino)ethyl group at position 2. It acts as a histamine agonist and a vasodilator, and is thought to improve the microcirculation of the labyrinth, resulting in reduced endolymphatic pressure. It is used (generally as the hydrochloride or mesylate salt) to reduce the symptoms of vertigo, tinnitus, and hearing loss associated with Mnire's disease. It has a role as a vasodilator agent and a H1-receptor agonist. It is an aminoalkylpyridine and a secondary amino compound.

CAS Number5638-76-6
PubChem CID2366
IUPAC NameN-methyl-2-pyridin-2-ylethanamine
Molecular FormulaC8H12N2
Molecular Weight136.19
XLogP0.4
Topological Polar Surface Area24.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Heavy Atom Count10
Formal Charge0
Complexity83
SMILES
CNCCC1=CC=CC=N1
InChI
InChI=1S/C8H12N2/c1-9-7-5-8-4-2-3-6-10-8/h2-4,6,9H,5,7H2,1H3
InChIKey
UUQMNUMQCIQDMZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Betahistine
CAS: 5638-76-6
CID: 2366
Formula: C8H12N2
MW: 136.19
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight136.19
XLogP30.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Exact Mass136.100048391
Monoisotopic Mass136.100048391
Topological Polar Surface Area24.9 Ų
Heavy Atom Count10
Formal Charge0
Complexity83.3
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5750058Betahistine
B1555-50Betahistine 2HCl
C6391-25Betahistine mesylate
FB138972-01Betahistine dihydrochloride
003888Betahistine Hydrochloride
HY-B0524A-01Betahistine (dihydrochloride)

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