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AG-494

CAT: 0013-GTR19169045-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19169045-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AG-494 (Tyrphostin B48) is a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. It is widely used in biochemical research to study EGFR signaling pathways in both cellular and animal models of proliferation and oncology.
CAS Number
133550-35-3
Product Name Alternative
CDK, activation, AG 494, AG494, AG-494, EGFR, osteogenic, Tyrphostin AG494, Tyrphostin AG-494, Tyrphostin B48, Tyrphostin AG 494
Field of Research
Cell Biology
Purity
>98%
Bioactivity
EGF receptor tyrosine kinase inhibitor
Form
Powder
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.14 mM) ; Ethanol:1.4 mg/mL (5 mM) ; DMSO:14 mg/mL (49.95 mM)
Smiles
Oc1ccc (\C=C (/C#N) C (=O) Nc2ccccc2) cc1O
Molecular Formula
C16H12N2O3
Molecular Weight
280.28
Storage Conditions
RT
Notes
For research use only.

Chemical Information

AG 494

Tyrphostin B48 is a member of the tyrphostin family of tyrosine kinase inhibitors that inhibits epidermal growth factor receptor. (NCI)

CAS Number133550-35-3
PubChem CID5328771
IUPAC Name(E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-2-enamide
Molecular FormulaC16H12N2O3
Molecular Weight280.28
XLogP2.7
Topological Polar Surface Area93.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count21
Formal Charge0
Complexity446
SMILES
C1=CC=C(C=C1)NC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N
InChI
InChI=1S/C16H12N2O3/c17-10-12(8-11-6-7-14(19)15(20)9-11)16(21)18-13-4-2-1-3-5-13/h1-9,19-20H,(H,18,21)/b12-8+
InChIKey
HKHOVJYOELRGMV-XYOKQWHBSA-N
Chemical Structure
2D Structure
2D structure of AG 494
CAS: 133550-35-3
CID: 5328771
Formula: C16H12N2O3
MW: 280.28
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight280.28
XLogP32.7
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass280.08479225
Monoisotopic Mass280.08479225
Topological Polar Surface Area93.4 Ų
Heavy Atom Count21
Formal Charge0
Complexity446
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

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254558-01AG 494
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A17142-100AG-494 100mg
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