NCT-503

CAT: 0013-GTR19169037-02Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19169037-02Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

NCT-503 is a selective phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=2.5 μM) with demonstrated antitumor activity. It is used in cancer metabolism research to suppress the growth of PHGDH-dependent tumors in both cellular and animal models.

CAS Number

1916571-90-8

Product Name Alternative

PHGDH (Cell-free), TAMReceptor, TAM Receptor, Inhibitor, FLT3, NCT 503, NCT503, NCT-503, inhibit, AXL

Field of Research

Cardiovascular Research, Metabolism Research, Signal Transduction

Purity

98.91% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:1.83 mg/mL (4.48 mM) ; Ethanol:75 mg/mL (183.61 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:127 mg/mL (310.91 mM)

Smiles

Cc1cc (C) nc (NC (=S) N2CCN (Cc3ccc (cc3) C (F) (F) F) CC2) c1

Molecular Formula

C20H23F3N4S

Molecular Weight

408.48

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

Nct-503

small molecule inhibitor of phosphoglycerate dehydrogenase (PHGDH)

CAS Number	1916571-90-8
PubChem CID	118796328
IUPAC Name	N-(4,6-dimethyl-2-pyridinyl)-4-[[4-(trifluoromethyl)phenyl]methyl]piperazine-1-carbothioamide
Molecular Formula	C20H23F3N4S
Molecular Weight	408.5
XLogP	3.9
Topological Polar Surface Area	63.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	3
Heavy Atom Count	28
Formal Charge	0
Complexity	514

SMILES

CC1=CC(=NC(=C1)NC(=S)N2CCN(CC2)CC3=CC=C(C=C3)C(F)(F)F)C

InChI

InChI=1S/C20H23F3N4S/c1-14-11-15(2)24-18(12-14)25-19(28)27-9-7-26(8-10-27)13-16-3-5-17(6-4-16)20(21,22)23/h3-6,11-12H,7-10,13H2,1-2H3,(H,24,25,28)

InChIKey

PJNSZIQUFLWRLH-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1916571-90-8

CID: 118796328

Formula: C20H23F3N4S

MW: 408.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	408.5
XLogP3	3.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	3
Exact Mass	408.15955241
Monoisotopic Mass	408.15955241
Topological Polar Surface Area	63.5 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	514
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
460613-01	NCT-503
A17132-100	NCT-503 100mg
A17132-50	NCT-503 50mg
A17132-10	NCT-503 10mg
A17132-25	NCT-503 25mg

NCT-503

Chemical Information

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