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STAT5-IN-1

CAT: 0013-GTR19169033-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19169033-01Size:5 mg
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Description
STAT5-IN-1 is a cell-permeable small molecule that inhibits STAT5 activity by targeting its SH2 domain. This inhibitor is utilized in research areas such as oncology and immunology for in vitro studies of cancers and hematological disorders where STAT5 signaling is implicated.
CAS Number
285986-31-4
Product Name Alternative
Inhibitor, inhibit, STAT5 IN 1, STAT5 Inhibitor, STAT5IN1, STAT-5-IN-1, STAT5-IN-1, STAT5β, STAT
Field of Research
Signal Transduction, Stem Cell & Developmental Biology
Purity
≥95% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.82 mM) ; DMSO:50 mg/mL (170.49 mM)
Smiles
O=C (N\N=C\c1coc2ccccc2c1=O) c1cccnc1
Molecular Formula
C16H11N3O3
Molecular Weight
293.28
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

STAT5 Inhibitor

N'-[(4-oxo-4H-chromen-3-yl)methylene]nicotinohydrazide is a carbohydrazide that is nicotinohydrazide in which the terminal nitrogen has undergone formal condensation with the aldehyde group of 4-oxo-4H-chromene-3-carbaldehyde. It is an inhibitor of STAT5 (Signal Transducer and Activator of Transcription 5) protein. It has a role as a signal transducer and activator of transcription 5 protein inhibitor. It is a member of chromones, a member of pyridines and a carbohydrazide.

CAS Number285986-31-4
PubChem CID9566174
IUPAC NameN-[(E)-(4-oxochromen-3-yl)methylideneamino]pyridine-3-carboxamide
Molecular FormulaC16H11N3O3
Molecular Weight293.28
XLogP1.6
Topological Polar Surface Area80.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count22
Formal Charge0
Complexity501
SMILES
C1=CC=C2C(=C1)C(=O)C(=CO2)/C=N/NC(=O)C3=CN=CC=C3
InChI
InChI=1S/C16H11N3O3/c20-15-12(10-22-14-6-2-1-5-13(14)15)9-18-19-16(21)11-4-3-7-17-8-11/h1-10H,(H,19,21)/b18-9+
InChIKey
DAVIKTBRCQWOGT-GIJQJNRQSA-N
Chemical Structure
2D Structure
2D structure of STAT5 Inhibitor
CAS: 285986-31-4
CID: 9566174
Formula: C16H11N3O3
MW: 293.28
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight293.28
XLogP31.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass293.08004122
Monoisotopic Mass293.08004122
Topological Polar Surface Area80.7 Ų
Heavy Atom Count22
Formal Charge0
Complexity501
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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