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Kurarinone

CAT: 0013-GTR19168894-07Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19168894-07Size:100 mg
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Description
Kurarinone, a bioactive flavonoid from Sophora flavescens, exhibits anti-tumor, estrogenic, and anti-inflammatory properties with potent immunosuppressive activity. It is widely used in pharmacological research, including in vitro cell-based assays and in vivo studies exploring its therapeutic potential in oncology and immunology.
CAS Number
34981-26-5
Product Name Alternative
Bcl-2, CD4 (+), inhibit, Kurarinone, IκB, JAK, NFκB, NF-kB, NFkB, NF-κB, Inhibitor, IkB/IKK, IkB, IKK, TNF-α, STAT
Field of Research
Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
97.85% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.56 mM) ; DMSO:55 mg/mL (125.42 mM)
Smiles
COc1cc (O) c (C[C@@H] (CC=C (C) C) C (C) =C) c2O[C@@H] (CC (=O) c12) c1ccc (O) cc1O
Molecular Formula
C26H30O6
Molecular Weight
438.51
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Kurarinone

(2S)-(-)-kurarinone is a trihydroxyflavanone that is (2S)-flavanone substituted by hydroxy groups at positions 7, 2' and 4', a lavandulyl group at position 8 and a methoxy group at position 5. Isolated from the roots of Sophora flavescens, it exhibits cytotoxicity against human myeloid leukemia HL-60 cells. It has a role as a metabolite and an antineoplastic agent. It is a member of 4'-hydroxyflavanones, a monomethoxyflavanone and a trihydroxyflavanone. It is functionally related to a (2S)-flavanone.

CAS Number34981-26-5
PubChem CID11982640
IUPAC Name(2S)-2-(2,4-dihydroxyphenyl)-7-hydroxy-5-methoxy-8-[(2R)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]-2,3-dihydrochromen-4-one
Molecular FormulaC26H30O6
Molecular Weight438.5
XLogP5.6
Topological Polar Surface Area96.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Heavy Atom Count32
Formal Charge0
Complexity698
SMILES
CC(=CC[C@H](CC1=C2C(=C(C=C1O)OC)C(=O)C[C@H](O2)C3=C(C=C(C=C3)O)O)C(=C)C)C
InChI
InChI=1S/C26H30O6/c1-14(2)6-7-16(15(3)4)10-19-21(29)12-24(31-5)25-22(30)13-23(32-26(19)25)18-9-8-17(27)11-20(18)28/h6,8-9,11-12,16,23,27-29H,3,7,10,13H2,1-2,4-5H3/t16-,23+/m1/s1
InChIKey
LTTQKYMNTNISSZ-MWTRTKDXSA-N
Chemical Structure
2D Structure
2D structure of Kurarinone
CAS: 34981-26-5
CID: 11982640
Formula: C26H30O6
MW: 438.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight438.5
XLogP35.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass438.20423867
Monoisotopic Mass438.20423867
Topological Polar Surface Area96.2 Ų
Heavy Atom Count32
Formal Charge0
Complexity698
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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