Mouse anti Fbxw7/Cdc4 [FBOX 3a9/1]: Horseradish peroxidase (HRP)

• Gene Name:

  [Fbxw7/Cdc4]

• NCBI Gene ID:

  55294

• Reactivity:

  Mouse, Human

• Specificity:

  This antibody recognises F-box/WD repeat-containing protein 7 (Fbxw7), which is also known as cdc4 and SEL-10. The FBW7/Cdc4 F-box protein was first recognized by its ability to bind cyclin E and the SCF (FBW7) is now known to target c-Myc, c-Jun and Notch for degradation in addition to its role in cyclin E proteolysis. FBW7 negatively regulates several key oncoproteins and is a tumour suppressor that is mutated in a wide spectrum of human cancers.

• Other Gene Names:

  [FBXW7; FBXW7; AGO; CDC4; FBW6; FBW7; hAgo; FBX30; FBXW6; SEL10; hCdc4; FBXO30; SEL-10; hAgo]

• Short Name:

  [Fbxw7/Cdc4]

• Other Product Names:

  [F-box/WD repeat-containing protein 7 isoform 4; F-box/WD repeat-containing protein 7; F-box/WD repeat-containing protein 7; F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila); F-box protein FBW7; F-box protein FBX30; F-box protein SEL-10; homolog of C elegans sel-10; F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase; Archipelago homolog]

• NCBI GI Number:

  379991109

• NCBI Accession Number:

  NP_001243998.1

• NCBI GB Accession Number:

  NM_001257069.1

• Uniprot Accession Number:

  Q969H0

• CAS Number:

  9007-83-4