Mouse anti Fbxw7/Cdc4 [FBOX 3a9/1]: Horseradish peroxidase (HRP)

Mouse anti Fbxw7/Cdc4 [FBOX 3a9/1]: Horseradish peroxidase (HRP)

• CAS Number: 9007-83-4
• Gene Name: [Fbxw7/Cdc4]
• NCBI Gene ID: 55294
• Reactivity: Mouse, Human
• Specificity: This antibody recognises F-box/WD repeat-containing protein 7 (Fbxw7), which is also known as cdc4 and SEL-10. The FBW7/Cdc4 F-box protein was first recognized by its ability to bind cyclin E and the SCF (FBW7) is now known to target c-Myc, c-Jun and Notch for degradation in addition to its role in cyclin E proteolysis. FBW7 negatively regulates several key oncoproteins and is a tumour suppressor that is mutated in a wide spectrum of human cancers.
• Other Gene Names: [FBXW7; FBXW7; AGO; CDC4; FBW6; FBW7; hAgo; FBX30; FBXW6; SEL10; hCdc4; FBXO30; SEL-10; hAgo]
• Short Name: [Fbxw7/Cdc4]
• Other Product Names: [F-box/WD repeat-containing protein 7 isoform 4; F-box/WD repeat-containing protein 7; F-box/WD repeat-containing protein 7; F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila); F-box protein FBW7; F-box protein FBX30; F-box protein SEL-10; homolog of C elegans sel-10; F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase; Archipelago homolog]
• NCBI GI Number: 379991109
• NCBI Accession Number: NP_001243998.1
• NCBI GB Accession Number: NM_001257069.1
• Uniprot Accession Number: Q969H0