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Q203

CAT: 0013-GTR19168469-04Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19168469-04Size:10 mg
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Description
Telacebec (Q203) is a potent small-molecule inhibitor targeting the cytochrome b subunit QcrB of Mycobacterium tuberculosis, exhibiting potent activity with an MIC50 of 2.7 nM against the H37Rv strain. It serves as a key research tool for investigating mycobacterial respiration and has demonstrated efficacy in both in vitro assays and in vivo mouse models of tuberculosis infection.
CAS Number
1334719-95-7
Product Name Alternative
Bacterial, Antibiotic, IAP 6, IAP6, IAP-6, Inhibitor, inhibit, Q 203, Q203, Q-203, tuberculosis, Telacebec
Field of Research
Infectious Disease & Virology
Purity
98.02% (May vary between batches)
Solubility
H2O:Insoluble; DMSO:11 mg/mL (19.75 mM)
Smiles
CCc1nc2ccc (Cl) cn2c1C (=O) NCc1ccc (cc1) N1CCC (CC1) c1ccc (OC (F) (F) F) cc1
Molecular Formula
C29H28ClF3N4O2
Molecular Weight
557.01
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Telacebec

a potent clinical candidate for the treatment of tuberculosis

CAS Number1334719-95-7
PubChem CID68234908
IUPAC Name6-chloro-2-ethyl-N-[[4-[4-[4-(trifluoromethoxy)phenyl]piperidin-1-yl]phenyl]methyl]imidazo[1,2-a]pyridine-3-carboxamide
Molecular FormulaC29H28ClF3N4O2
Molecular Weight557.0
XLogP7.9
Topological Polar Surface Area58.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count39
Formal Charge0
Complexity796
SMILES
CCC1=C(N2C=C(C=CC2=N1)Cl)C(=O)NCC3=CC=C(C=C3)N4CCC(CC4)C5=CC=C(C=C5)OC(F)(F)F
InChI
InChI=1S/C29H28ClF3N4O2/c1-2-25-27(37-18-22(30)7-12-26(37)35-25)28(38)34-17-19-3-8-23(9-4-19)36-15-13-21(14-16-36)20-5-10-24(11-6-20)39-29(31,32)33/h3-12,18,21H,2,13-17H2,1H3,(H,34,38)
InChIKey
OJICYBSWSZGRFB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Telacebec
CAS: 1334719-95-7
CID: 68234908
Formula: C29H28ClF3N4O2
MW: 557.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight557.0
XLogP37.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass556.1852883
Monoisotopic Mass556.1852883
Topological Polar Surface Area58.9 Ų
Heavy Atom Count39
Formal Charge0
Complexity796
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS3601336-01Q203
A12310-1Q203 1mg
A12310-10Q203 10mg
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A12310-5Q203 5mg
A12310-25Telacebec (Q203) 25mg
BS2003Hox-A1 (Q203) polyclonal antibody
A12310-10mM-DTelacebec (Q203) 10mM * 1mL in DMSO
A03416Anti-Hox-A1 (Q203) Antibody

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