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SB 415286

CAT: 0013-GTR19168203-02Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19168203-02Size:1 ml x 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SB 415286 is a potent and selective ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK-3), exhibiting IC50 values of 78 nM and 31 nM for GSK-3α and GSK-3β, respectively. This cell-permeable compound is widely used in vitro and in vivo to investigate GSK-3's role in Wnt/β-catenin signaling, neurodegenerative diseases, and glucose metabolism.
CAS Number
264218-23-7
Product Name Alternative
GSK-3α/β, GSK-3, GSK3, Glycogen synthase kinase-3, Glycogen synthase kinase 3, Inhibitor, inhibit, Apoptosis, SB 415286, SB415286, SB-415286
Field of Research
Cell Biology, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.55% (May vary between batches)
Solubility
DMSO:18 mg/mL (50.04 mM) ; Ethanol:9 mg/mL (25.02 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.56 mM)
Smiles
Oc1ccc (NC2=C (C (=O) NC2=O) c2ccccc2[N+] ([O-]) =O) cc1Cl
Molecular Formula
C16H10ClN3O5
Molecular Weight
359.72
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

SB 415286

SB 415286 is a member of the class of maleimides carrying 3-chloro-4-hydroxyphenylamino and 2-nitrophenyl substituents at positions 3 and 4 respectively. It has a role as an antioxidant, a neuroprotective agent, an apoptosis inducer and an EC 2.7.11.26 (tau-protein kinase) inhibitor. It is a member of phenols, a C-nitro compound, a substituted aniline, a secondary amino compound, a member of maleimides and a member of monochlorobenzenes.

CAS Number264218-23-7
PubChem CID4210951
IUPAC Name3-(3-chloro-4-hydroxyanilino)-4-(2-nitrophenyl)pyrrole-2,5-dione
Molecular FormulaC16H10ClN3O5
Molecular Weight359.72
XLogP2.8
Topological Polar Surface Area124
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count25
Formal Charge0
Complexity617
SMILES
C1=CC=C(C(=C1)C2=C(C(=O)NC2=O)NC3=CC(=C(C=C3)O)Cl)[N+](=O)[O-]
InChI
InChI=1S/C16H10ClN3O5/c17-10-7-8(5-6-12(10)21)18-14-13(15(22)19-16(14)23)9-3-1-2-4-11(9)20(24)25/h1-7,21H,(H2,18,19,22,23)
InChIKey
PQCXVIPXISBFPN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of SB 415286
CAS: 264218-23-7
CID: 4210951
Formula: C16H10ClN3O5
MW: 359.72
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight359.72
XLogP32.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass359.0308981
Monoisotopic Mass359.0308981
Topological Polar Surface Area124 Ų
Heavy Atom Count25
Formal Charge0
Complexity617
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
B1954-25SB-415286
GL2098-5mgSB 415286
A11061-100SB 415286 100mg
A11061-25SB 415286 25mg
A11061-50SB 415286 50mg
A11061-10SB 415286 10mg
HY-15438R-01SB 415286 (Standard)
A11061-5SB 415286 5mg
A11061-10mM-DSB 415286 10mM * 1mL in DMSO

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