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AM-80

CAT: 0013-GTR19168169-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19168169-01Size:10 mg
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Description
Tamibarotene is a synthetic oral retinoid developed to target ATRA-resistant cancers. It exhibits antineoplastic activity and is utilized in oncology research, particularly for acute promyelocytic leukemia (APL), with studies conducted in both cellular and animal models.
CAS Number
94497-51-5
Product Name Alternative
Tamibarotene; NSC608000; Retinobenzoic acid
Field of Research
Immunology & Inflammation, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
RARa agonist
Form
Powder
Solubility
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 18 mg/ml) .
Smiles
CC1 (C) C=2C (=CC (NC (=O) C3=CC=C (C (O) =O) C=C3) =CC2) C (C) (C) CC1
Molecular Formula
C22H25NO3
Molecular Weight
351.4
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
4-[[ (5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl) amino]-carbonyl]benzoic acid

Chemical Information

Tamibarotene

Tamibarotene is a dicarboxylic acid monoamide resulting from the condensation of one of the carboxy groups of terephthalic acid with the amino group of 5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-amine. It has a role as an antineoplastic agent and a retinoic acid receptor alpha/beta agonist. It is a retinoid, a dicarboxylic acid monoamide and a member of tetralins. It is functionally related to a terephthalic acid and a 4-carbamoylbenzoic acid.

CAS Number94497-51-5
PubChem CID108143
IUPAC Name4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid
Molecular FormulaC22H25NO3
Molecular Weight351.4
XLogP5.4
Topological Polar Surface Area66.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count26
Formal Charge0
Complexity546
SMILES
CC1(CCC(C2=C1C=CC(=C2)NC(=O)C3=CC=C(C=C3)C(=O)O)(C)C)C
InChI
InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-16(9-10-17(18)21)23-19(24)14-5-7-15(8-6-14)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)
InChIKey
MUTNCGKQJGXKEM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Tamibarotene
CAS: 94497-51-5
CID: 108143
Formula: C22H25NO3
MW: 351.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight351.4
XLogP35.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass351.18344366
Monoisotopic Mass351.18344366
Topological Polar Surface Area66.4 Ų
Heavy Atom Count26
Formal Charge0
Complexity546
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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