Products for Research Use Only
RegisterLogin

AG-879

CAT: 0013-GTR19168150-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19168150-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Tyrphostin AG 879 is a selective inhibitor of the HER2/ErbB2 tyrosine kinase, demonstrating potent activity with an IC50 of 1 μM. It exhibits 100- to 500-fold selectivity for HER2 over EGFR and PDGFR, making it a valuable tool for investigating HER2-driven signaling in cancer research, both in cellular and animal models.
CAS Number
148741-30-4
Product Name Alternative
ErbB-1, ErbB2, EGFR, Epidermal growth factor receptor, HER2-Neu, HER1, Inhibitor, p75, inhibit, Apoptosis, Antitumor, antiproliferation, AG879, AG-879, AG 879, PDGFR, phosphorylation, Tyrphostin AG 879, Tyrphostin AG879, Tyrphostin AG-879, tyrosine, Tropomyosin related kinase receptor, Trkreceptor, Trk, Trk receptor, Trk Receptor, TrKA
Field of Research
Neuroscience
Purity
>98%
Bioactivity
NGFR kinase inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml) .
Smiles
CC (C) (C) c1cc (\C=C (/C#N) C (N) =S) cc (c1O) C (C) (C) C
Molecular Formula
C18H24N2OS
Molecular Weight
316.47
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
3,5-Di-t-butyl-4-hydroxybenzylidene cyanothioacetamide

Chemical Information

2-Propenethioamide, 3-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)-2-cyano-, (E)-

3-amino-2-[(3,5-ditert-butyl-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-3-mercapto-2-propenenitrile is a monoterpenoid.

CAS Number148741-30-4
PubChem CID135419190
IUPAC Name(E)-2-cyano-3-(3,5-ditert-butyl-4-hydroxyphenyl)prop-2-enethioamide
Molecular FormulaC18H24N2OS
Molecular Weight316.5
XLogP4.7
Topological Polar Surface Area102
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count22
Formal Charge0
Complexity477
SMILES
CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)/C=C(\C#N)/C(=S)N
InChI
InChI=1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,21H,1-6H3,(H2,20,22)/b12-7+
InChIKey
XRZYELWZLNAXGE-KPKJPENVSA-N
Chemical Structure
2D Structure
2D structure of 2-Propenethioamide, 3-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)-2-cyano-, (E)-
CAS: 148741-30-4
CID: 135419190
Formula: C18H24N2OS
MW: 316.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight316.5
XLogP34.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass316.16093457
Monoisotopic Mass316.16093457
Topological Polar Surface Area102 Ų
Heavy Atom Count22
Formal Charge0
Complexity477
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19258626-01AXC-879
GTR19307033-01Mmu-miR-879-3p miRNA Inhibitor
GTR19307032-01Mmu-miR-879-3p miRNA Mimic
GTR19293722-01Rno-miR-879-3p miRNA Agomir
GTR19293720-01Rno-miR-879-3p miRNA Inhibitor
GTR19293718-01Rno-miR-879-5p miRNA Agomir
GTR19307031-01Mmu-miR-879-5p miRNA Agomir
GTR19307030-01Mmu-miR-879-5p miRNA Antagomir
GTR19307029-01Mmu-miR-879-5p miRNA Inhibitor
GTR19293715-01Rno-miR-879-5p miRNA Mimic

Alternative Products

CatalogName
524142AG 879
MBS515054-01AG-879
T6712-01Tyrphostin AG 879

Popular Products