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HS-1371

CAT: 0013-GTR19168058-03Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19168058-03Size:1 ml x 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HS-1371 is a potent and selective small molecule inhibitor of RIP3 kinase, demonstrating an IC50 of 20.8 nM. It is a valuable research tool for investigating necroptosis in vitro and has been utilized in preclinical in vivo models to study inflammatory and ischemic diseases.
CAS Number
2158197-70-5
Product Name Alternative
HS1371, HS-1371, HS 1371, inhibit, Inhibitor, Receptor-interacting protein kinases, RIPkinase, RIP3, RIPK, RIP kinase
Field of Research
Cell Biology, Signal Transduction
Purity
95.20% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.6 mM) ; DMSO:16.67 mg/mL (43.36 mM)
Smiles
Cc1ccc (Oc2ccnc3cc (ccc23) -c2cnn (c2) C2CCNCC2) cc1
Molecular Formula
C24H24N4O
Molecular Weight
384.47
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

7-(1-(Piperidin-4-yl)-1h-pyrazol-4-yl)-4-(p-tolyloxy)quinoline
CAS Number2158197-70-5
PubChem CID134817449
IUPAC Name4-(4-methylphenoxy)-7-(1-piperidin-4-ylpyrazol-4-yl)quinoline
Molecular FormulaC24H24N4O
Molecular Weight384.5
XLogP4
Topological Polar Surface Area52
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count29
Formal Charge0
Complexity517
SMILES
CC1=CC=C(C=C1)OC2=C3C=CC(=CC3=NC=C2)C4=CN(N=C4)C5CCNCC5
InChI
InChI=1S/C24H24N4O/c1-17-2-5-21(6-3-17)29-24-10-13-26-23-14-18(4-7-22(23)24)19-15-27-28(16-19)20-8-11-25-12-9-20/h2-7,10,13-16,20,25H,8-9,11-12H2,1H3
InChIKey
VPVLPCIBKVWFDT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 7-(1-(Piperidin-4-yl)-1h-pyrazol-4-yl)-4-(p-tolyloxy)quinoline
CAS: 2158197-70-5
CID: 134817449
Formula: C24H24N4O
MW: 384.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight384.5
XLogP34
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass384.19501140
Monoisotopic Mass384.19501140
Topological Polar Surface Area52 Ų
Heavy Atom Count29
Formal Charge0
Complexity517
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
BA3498-100HS-1371
A18653-100HS-1371 100mg
A18653-50HS-1371 50mg
A18653-10HS-1371 10mg
A18653-5HS-1371 5mg
A18653-25HS-1371 25mg
A18653-1HS-1371 1mg
A18653-10mM-DHS-1371 10mM * 1mL in DMSO
BH300142HS-1371 - Bio-X TM

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